Bile acid composition and glucose metabolism

Diabetes patients need to manage multiple metabolic dysfunctions, including hyperglycemia, fatty liver disease, high triglycerides, high cholesterol, cardiovascular disease, and obesity, but current therapies do not sufficiently treat all of these maladies in an integrated manner. We have identified the enzyme Cyp8b1 as a potential new therapeutic target that would benefit glycemia as well as diabetes complications. Understanding the relationships between Cyp8b1 and insulin resistance, obesity, lipid metabolism, and glycemia may improve our ability to treat patients more effectively.