Cardiovascular autophagy Concepts, controversies, and perspectives

Sergio Lavandero; Rodrigo Troncoso; Beverly A. Rotherme; Wim Martinet; Junichi Sadoshima; Joseph A. Hill

doi:10.4161/auto.25969

Cardiovascular autophagy Concepts, controversies, and perspectives

Sergio Lavandero, Rodrigo Troncoso, Beverly A. Rotherme, Wim Martinet, Junichi Sadoshima, Joseph A. Hill

Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

152 Citations (Scopus)

Abstract

Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP₃, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.

Original language	English
Pages (from-to)	1455-1466
Number of pages	12
Journal	Autophagy
Volume	9
Issue number	10
DOIs	https://doi.org/10.4161/auto.25969
Publication status	Published - Oct 2013

Bibliographical note

Funding Information:
This work was supported by Grants from CONICYT, Chile (FONDECYT 1120212 and FONDECYT 3110114 to SL and RT, respectively; Anillo ACT grant 1111 to SL, Red 120003 to SL and JAH), the NIH (HL-080144, JAH; HL-0980842, JAH; HL-100401, JAH; HL-072016, BAR; HL-097768, BAR), CPRIT (RP110486P3, JAH), the AHA DeHaan Foundation (0970518N, JAH), and the Fondation Leducq (11CVD04, JAH).

Funding

This work was supported by Grants from CONICYT, Chile (FONDECYT 1120212 and FONDECYT 3110114 to SL and RT, respectively; Anillo ACT grant 1111 to SL, Red 120003 to SL and JAH), the NIH (HL-080144, JAH; HL-0980842, JAH; HL-100401, JAH; HL-072016, BAR; HL-097768, BAR), CPRIT (RP110486P3, JAH), the AHA DeHaan Foundation (0970518N, JAH), and the Fondation Leducq (11CVD04, JAH).

Funders	Funder number
AHA DeHaan Foundation	0970518N
CONICYT, Chile
National Institutes of Health	HL-0980842, HL-100401, HL-080144, HL-072016
National Heart, Lung, and Blood Institute	R01HL097768
Cancer Prevention and Research Institute of Texas	RP110486P3
Fondation Leducq	11CVD04
Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica	1120212, 120003, 3110114, 1111

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

Access to Document

10.4161/auto.25969

Cite this

@article{f1b5c38718564776aba4ddbeddce4128,

title = "Cardiovascular autophagy Concepts, controversies, and perspectives",

abstract = "Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP3, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.",

author = "Sergio Lavandero and Rodrigo Troncoso and Rotherme, {Beverly A.} and Wim Martinet and Junichi Sadoshima and Hill, {Joseph A.}",

note = "Funding Information: This work was supported by Grants from CONICYT, Chile (FONDECYT 1120212 and FONDECYT 3110114 to SL and RT, respectively; Anillo ACT grant 1111 to SL, Red 120003 to SL and JAH), the NIH (HL-080144, JAH; HL-0980842, JAH; HL-100401, JAH; HL-072016, BAR; HL-097768, BAR), CPRIT (RP110486P3, JAH), the AHA DeHaan Foundation (0970518N, JAH), and the Fondation Leducq (11CVD04, JAH).",

year = "2013",

month = oct,

doi = "10.4161/auto.25969",

language = "English",

volume = "9",

pages = "1455--1466",

journal = "Autophagy",

issn = "1554-8627",

publisher = "Landes Bioscience",

number = "10",

}

TY - JOUR

T1 - Cardiovascular autophagy Concepts, controversies, and perspectives

AU - Lavandero, Sergio

AU - Troncoso, Rodrigo

AU - Rotherme, Beverly A.

AU - Martinet, Wim

AU - Sadoshima, Junichi

AU - Hill, Joseph A.

N1 - Funding Information: This work was supported by Grants from CONICYT, Chile (FONDECYT 1120212 and FONDECYT 3110114 to SL and RT, respectively; Anillo ACT grant 1111 to SL, Red 120003 to SL and JAH), the NIH (HL-080144, JAH; HL-0980842, JAH; HL-100401, JAH; HL-072016, BAR; HL-097768, BAR), CPRIT (RP110486P3, JAH), the AHA DeHaan Foundation (0970518N, JAH), and the Fondation Leducq (11CVD04, JAH).

PY - 2013/10

Y1 - 2013/10

N2 - Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP3, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.

AB - Abbreviations: AMPK, AMP-activated protein kinase; ATG, autophagy-related; ER, endoplasmic reticulum; GSK3B/GSK-3β glycogen synthase kinase 3 beta; HDAC, histone deacetylase; HDACi, HDAC inhibitor; IP3, inositol 1,4,5-trisphosphate; I/R, ischemia/reperfusion; ITPR, inositol 1,4,5-trisphosphate receptor; LC3, microtubule-associated protein 1 light chain 3 (homolog of yeast Atg8); MTOR, mechanistic target of rapamycin; NAD+, nicotinamide adenine dinucleotide; PIK3C3/VSP34, phosphatidylinositol 3-kinase, catalytic subunit type 3; PKA, cAMP-dependent protein kinase; PtdIns3K, phosphatidylinositol 3-kinase; ULK, unc-51 like autophagy activating kinase; VSMC, vascular smooth muscle cells; WDFY3/ALFY, WD repeat and FYVE domain containing 3.

UR - http://www.scopus.com/inward/record.url?scp=84885580133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885580133&partnerID=8YFLogxK

U2 - 10.4161/auto.25969

DO - 10.4161/auto.25969

M3 - Review article

C2 - 23959233

AN - SCOPUS:84885580133

SN - 1554-8627

VL - 9

SP - 1455

EP - 1466

JO - Autophagy

JF - Autophagy

IS - 10

ER -

Cardiovascular autophagy Concepts, controversies, and perspectives

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this