Columbia University Irving Medical Center

Proyectos

Proyectos por año 1984 2009 2022 2023 2024 2028

• 17 No iniciado
• 704 Activo
• 2419 Terminado

Proyectos por año

Resultados de la búsqueda

• Terminado

  Research Capacity Building Core

  Denny, L. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Capacity Building 100%
  • Implementation Science 100%
  • Cutting Edge 100%
  • Sustainable Building 100%
  • Application Development 100%

• Computational and theoretical understanding of regulatory mechanisms shaping natural vision

  Toosi, T. (PI)

  9/1/23 → 6/30/24

  Proyecto

  • Computer Vision 100%
  • Regularization 100%
  • Natural Image 50%
  • Scale Model 50%
  • Theoretical Framework 25%

• Structure and mechanism of pendrin and the mutations that cause Pendred's Syndrome

  Quick, M. M. (PI) & Zhou, M. (CoPI)

  9/1/23 → 5/31/24

  Proyecto

  • Pendrin 100%
  • Pendred Syndrome 100%
  • Syndrome 21%
  • Niflumic Acid 14%
  • Binding Site 14%

• Methods for inferring and analyzing gene regulatory networks using single-cell multiomics and spatial genomics data

  Hou, W. W. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Gene Control 100%
  • Gene Regulatory Network 100%
  • Genomics 100%
  • Transcriptomics 22%
  • Epigenomics 22%

• Immune and transcriptomic biomarkers of progressive oral premalignant lesions

  Momen Heravi, F. F. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Biological Marker 100%
  • Leukoplakia 100%
  • Transcriptomics 100%
  • Disease 100%
  • Immunity 100%

• Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors

  Baldwin, M. R. (PI)

  9/1/23 → 7/31/24

  Proyecto

  • Acute Respiratory Distress Syndrome 100%
  • Immunity 100%
  • Adult Respiratory Distress Syndrome 100%
  • Biological Marker 18%
  • Mitochondrial Disorder 18%

• Project 1: Identifying and optimizing monogenetic risk prediction for autism in newborns

  Chung, W. W. K. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Genetics 100%
  • Genetic Divergence 100%
  • Genetic Risk 100%
  • Genomics 100%
  • Urban Population 66%

• Examining Individuals' Exposure to Alcohol Environments Using Novel Responsive Buffers

  Mehranbod, C. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Risk Factor 100%
  • Systematic Review 100%
  • Research and Development 100%
  • Alcohol Consumption 100%
  • Individual Level 100%

• Physical activity, physical function, and frailty in relation to cognitive impairment and AD/ADRD biomarkers in DPPOS

  Palta, P. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Biological Marker 100%
  • Physical Activity 100%
  • Frailty 100%
  • Cognitive Defect 100%
  • Cognitive Disorders 100%

• Biostatistics and Data Infrastructure core

  Temprosa, M. M. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Data Infrastructure 100%
  • Prevention Program 100%
  • Biostatistics 100%
  • Alzheimer's Disease 100%
  • Data Management 66%

• Administrative Core

  Luchsinger, J. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Administrative Structure 100%
  • Diabetes Prevention 100%
  • Diseases 80%
  • Alzheimer's Disease 66%
  • Education Program 40%

• ECM remodeling and crosstalk with cell fate in zebrafish ligament regeneration

  Mo, J. J. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Legumain 100%
  • Cell Fate 100%
  • Zebra Fish 100%
  • Macrophage 55%
  • Cysteine Protease 11%

• Administrative Core

  Califano, A. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Pilot Project 100%
  • Steering Committee 100%
  • Administrative Structure 100%
  • Progress Report 50%
  • Metrics 50%

• Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

  Izar, B. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Cancer Cell 100%
  • Tumor Progression 100%
  • Drug Resistance 66%
  • Immunity 66%
  • Human Study 33%

• Drug Mechanism of Action-based targeting of tumor subpopulations

  Califano, A. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Immune Checkpoints 100%
  • Small Molecule 100%
  • Oncogene 100%
  • Drug Mechanism 100%
  • Mouse Model 100%

• Outreach Core

  Murray, D. D. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Outreach 100%
  • Therapy 100%
  • Systems Biology 36%
  • Secondary Schools 36%
  • Scientists 27%

• Advanced Single Cell Technology Innovation Core

  Sims, P. P. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • RNA Sequencing 100%
  • Malignant Neoplasm 100%
  • RNA 100%
  • Analytic Method 50%
  • Neoplasm 50%

• Project 3: A Transdisciplinary Approach to Increasing Phytonutrients in New Mexican Diets: A Kitchen-to-Lab-to-Table Model

  Greenlee, H. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Phytonutrients 100%
  • Chlorophyll 100%
  • Carotenoid 100%
  • Diet Quality 75%
  • Tocopherol 50%

• Uncovering novel mechanisms and potential therapeutic targets for IgA vasculitis through GWAS and systems-level analysis of regulatory networks.

  Liu, L. L. (PI)

  8/24/23 → 5/31/24

  Proyecto

  • IgA Vasculitis 100%
  • Genome Wide Association Study 100%
  • Regulatory Network 100%
  • Genetics 100%
  • Immunoglobulin A 100%

• Health Disparities in Hospice in Nursing Homes

  Stone, P. W. (PI), Dick, A. W. (CoPI) & Dhingra, L. (CoPI)

  8/23/23 → 6/30/24

  Proyecto

  • Nursing Home 100%
  • Health Disparity 100%
  • Hospice Care 40%
  • Terminal Care 20%
  • End of Life Care 20%

• Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma

  Taylor, A. A. M. (PI)

  8/21/23 → 7/31/24

  Proyecto

  • Aneuploidy 100%
  • Chromosome 3 100%
  • Chromosome Arm 50%
  • Chromosome 3q 50%
  • Carcinogenesis 33%

• Architecture, dynamics and regulation of erythrocyte ankyrin-1 complexes

  Clarke, O. O. B. (PI)

  8/20/23 → 7/31/24

  Proyecto

  • Dynamics 100%
  • Ankyrin 100%
  • Band 3 30%
  • Membrane Protein 30%
  • Transmembrane Protein 30%

• Development and application of a quantitive model for HIV-1 transcriptional activation driven by TAR RNA conformational dynamics

  Al-hashimi, H. H. M. (PI), Herschlag, D. D. (CoPI) & Goff, S. S. P. (CoPI)

  8/17/23 → 7/31/24

  Proyecto

  • Dynamics 100%
  • Human Immunodeficiency Virus 1 100%
  • Transcription Initiation 100%
  • RNA 100%
  • Transactivation 100%

• NY Community-Hospital-Academic Maternal Health Equity Partnerships (NY-CHAMP)

  Reddy, U. U. (PI), Rodriguez, E. E. (CoPI), Li, G. G. (CoPI), Taylor, J. J. Y. (CoPI), Hall, K. K. S. (CoPI), Osborne, L. L. M. (CoPI), Dorval-moller, M. M. (CoPI), Safford, M. M. M. (CoPI), Brown, S. S. (CoPI) & St. Clair, V. V. (CoPI)

  8/17/23 → 7/31/24

  Proyecto

  • Maternal Welfare 100%
  • Health Disparity 12%
  • Patient Care 12%
  • Health Care Cost 12%
  • Cognitive Behavioral Therapy 12%

• Non-APOL1 genetic factors and kidney transplant outcomes

  Kiryluk, K. K. (PI)

  8/15/23 → 5/31/24

  Proyecto

  • Heredity 100%
  • Kidney Graft 100%
  • Kidney Transplantation 100%
  • Genetics 100%
  • Genetic Determinism 100%

• Investigating the role of long-term latent herpes simplex virus infection on APOE4-associated Alzheimer's disease pathogenesis

  Nuriel, T. T. (PI) & Cliffe, A. A. R. (CoPI)

  8/15/23 → 4/30/24

  Proyecto

  • Virus Infection 100%
  • Human Alphaherpesvirus 1 100%
  • Herpes Simplex Virus 100%
  • Alzheimer's Disease 100%
  • Infection 83%

• Impact of Environmental Exposures on Lung Immunity over Age

  Ural, B. B. (PI)

  8/15/23 → 4/30/24

  Proyecto

  • Environmental Exposure 100%
  • Macrophage 100%
  • Lung 100%
  • Diseases 100%
  • Lymph Node 71%

• Molecular Mechanisms of MDS pathogenesis with aging

  Kousteni, S. S. (PI)

  8/15/23 → 4/30/24

  Proyecto

  • Nucleoporin 100%
  • Stem Cell 37%
  • Hematopoiesis 12%
  • NUP98 12%
  • Molecular Genetics 12%

• Identification of smooth muscle cell genes causal in atherosclerotic plaque stability and cardiovascular disease risk

  Reilly, M. M. P. (PI) & Saleheen, D. D. (CoPI)

  8/10/23 → 6/30/24

  Proyecto

  • Mouse Model 100%
  • Single Nucleotide Polymorphism 66%
  • Pleiotropy 66%
  • RNA 66%
  • Genetics 33%

• Decoding the Interferome by Mapping Genetic Interactions in Human Tissue

  Gaudet, R. R. G. (PI)

  8/10/23 → 7/31/24

  Proyecto

  • Interferon-Stimulated Gene 100%
  • Human Tissue 100%
  • Gene Interaction 100%
  • Immunocompetent Cell 50%
  • Interferon Type I 25%

• Role of long non-coding RNAs in exosome biogenesis

  Momen Heravi, F. F. (PI)

  8/10/23 → 7/31/24

  Proyecto

  • Biogenesis 100%
  • Long Non-Coding RNA 100%
  • Exosome 100%
  • Long Noncoding RNA 66%
  • Cell Communication 33%

• Insulin regulation of hepatic transport

  Haeusler, R. R. A. (PI)

  8/9/23 → 5/31/24

  Proyecto

  • Bile Acid 100%
  • Bile 25%
  • Hepatocyte 25%
  • Insulin Resistance 12%
  • Public Health 12%

• SEARCH: SMS Electronic Adolescent Reminders for Completion of HPV vaccination- Uganda

  Stockwell, M. S. (PI) & Kitaka, S. B. (CoPI)

  8/1/23 → 7/31/24

  Proyecto

• 2/4-The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopschosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease

  Verna, E. E. C. (PI)

  8/1/23 → 7/31/24

  Proyecto

• Engineered Hydrogel Elucidates the Contribution of ECM Stiffness to Barrett's Esophagus Pathogenesis

  Cruz Acuña, R. R. (PI)

  8/1/23 → 4/30/24

  Proyecto

  • Esophagus 100%
  • Rigidity 100%
  • Barrett Esophagus 100%
  • Metaplasia 20%
  • Organoid 20%

• Clearance of Dead Hepatocytes by Liver Macrophages in NASH

  Shi, H. H. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Macrophage 100%
  • Nonalcoholic Fatty Liver 100%
  • Hepatocyte 100%
  • Steatohepatitis 100%
  • Efferocytosis 22%

• Broad spectrum inhibitors of paramyxovirus envelope proteins

  Moscona, A. A. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Envelope Protein 100%
  • Paramyxoviridae 100%
  • Peptides 100%
  • Antivirus Agent 75%
  • Lipopeptide 75%

• 3D Culture Models of Partial-EMT and Its Regulation in Oral Cavity Squamous Cell Carcinoma

  Parikh, A. A. S. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Oral Cavity 100%
  • Epithelial Mesenchymal Transition 100%
  • Squamous Cell Carcinoma 100%
  • TGFBI 100%
  • Growth Factor 77%

• Genetic and neuroanatomical basis of neuropsychiatric symptoms in Alzheimer's disease in populations of diverse ancestry

  Reitz, C. C. (PI), Huey, E. E. D. (CoPI) & Beecham, G. G. W. (CoPI)

  8/1/23 → 7/31/24

  Proyecto

  • Genetics 100%
  • Genomics 50%
  • Genetic Architecture 25%
  • FUS 25%
  • Genetic Risk 25%

• Impact of nucleotide metabolism on bacterial clearance

  Riquelme Colet, S. S. A. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Dihydroorotate Dehydrogenase 100%
  • Bacterial Clearance 100%
  • Nucleotide Metabolism 100%
  • Airway 100%
  • Infectious Agent 80%

• Dissecting the synaptic and circuit mechanisms underlying olfactory-driven social behavior

  Rodriguez, E. E. J. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Spectrum Disorder 100%
  • Social Behavior 100%
  • Behavior (Neuroscience) 100%

• Transcriptional regulation of urothelial differentiation and cell type specification during homeostasis and regeneration

  Mendelsohn, C. C. L. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Homeostasis 100%
  • Urology 100%
  • Urinary Tract Infection 100%
  • Regeneration 100%
  • Lower Urinary Tract Symptom 50%

• Human genetic approaches to lower urinary tract phenotypes

  Gharavi, A. A. G. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Human Genetics 100%
  • Urinary Tract 100%
  • Vesicoureteral Reflux 100%
  • Genome-Wide Association Study 100%
  • Genetic Approach 100%

• Opportunities Fund Management Core

  Amundson, S. S. A. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Progress Report 100%
  • Pilot Project 100%
  • Translational Research 100%
  • Review Process 50%
  • Standard Operating Procedure 50%

• Biostatistics Core

  Shuryak, I. I. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Biological System 100%
  • Dose Rate 100%
  • Design of Experiments 100%
  • Learning System 100%
  • Transcriptomics 100%

• Irradiation & Dosimetry Core

  Garty, G. G. Y. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Dosimetry 100%
  • Caesium-137 28%
  • in Vivo Dosimetry 14%
  • Ex Vivo 14%
  • Chest 14%

• Animal Core

  Ponnaiya, B. B. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Transgenic Mouse 100%
  • Biological Marker 100%
  • Cesium 137 100%
  • Lung Disease 100%
  • Blood Cell Count 100%

• Nuclear envelope and predisposition to hepatic neoplasia

  Shin, J.-Y. J. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Isoform 100%
  • Nuclear Membrane 100%
  • Nuclear Pore 100%
  • Hepatocyte 66%
  • Carcinogenesis 33%

• Deciphering the mechanism of non-canonical cell cycle entry

  Yang, H. W. H. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Cyclin Dependent Kinase 6 100%
  • Cyclin Dependent Kinase 4 100%
  • Cell Cycle 100%
  • Cyclin-Dependent Kinase 6 56%
  • Cyclin-Dependent Kinase 4 56%

• CE19-001, The Columbia Center for Injury Science and Prevention (CCISP)

  Branas, C. C. C. (PI)

  8/1/23 → 7/31/24

  Proyecto

  • Education Program 100%
  • Injury Prevention 100%