Biomarker Driven, Parcel-Guided TMS for Suicidal Thoughts and Behaviors in Depression

Patients with suicidal thoughts and behaviors (STBs) often report suicide-related imagery during a crisis. Mounting evidence suggests that brain function and connections between the frontal and visual parts of the brain are disrupted in patients with STBs. There is growing interest in the use of Transcranial Magnetic Stimulation (TMS) as a treatment for STBs. We aim to test a new TMS treatment, targeting the fronto-visual pathway in patients with treatment resistant depression and active STBs to relieve suicidal ideation and behavior.