Characterization of HIV-1 IgA bNAbs and ADCP function

Project Narrative PUBLIC HEALTH RELEVANCE: HIV-1 spreads mainly through mucosal exposures. Dominant in mucosal secretions, IgA has long been the class of antibodies desired at the portal of entrance to block infection; however, anti-HIV-1 IgA antibodies have been understudied. We therefore propose to identify and functionally characterize anti-HIV-1 IgA bNAbs and ADCP that are highly relevant to HIV-1 prevention and therapy.