Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT

Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT Narrative: The dosing of drugs with a narrow therapeutic index in hemodynamically unstable patients, such as those on continuous renal replacement therapy (CRRT), is exceptionally challenging and necessitates a personalized approach tailored in real-time to each patient’s changing conditions. Building on our recent demonstrations of closed-loop feedback control over plasma drug levels in a living animal, we propose the development and validation of a first-in-class approach to performing real-time therapeutic drug monitoring of extracorporeal clearance in sepsis patients undergoing CRRT. This will enable the rapid, personalized adjustment of antibiotic dosing in grievously ill patients for whom the margin for therapeutic error is smallest.