Project Details
Description
For some years this laboratory has tested hypotheses which directly or
indirectly related to the question of the etiology of trisomy in human
subjects. These experiments have been endocrinologic, biochemical and
cytogenetic. The present application deals directly with the diplotene
stage of mouse and human meiosis with special attention to chiasmata number
and location. The development of a capability for exact identification of
each bivalent at diplotene makes it possible for the first time to test in
mammals the basic genetical concepts of determination of chiasma number and
location, sexual dimorphism, terminalization, and interchromosomal effects
of structural or numerical abnormalities on chiasmata.
| Status | Finished |
|---|---|
| Effective start/end date | 7/1/85 → 1/1/90 |
Funding
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
ASJC Scopus Subject Areas
- Genetics
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