Project Details
Description
The engineering of living cells and microbes is a transformative approach to cancer therapy, as cells can be
genetically programmed to intelligently sense and respond to environments potentially leading to improved safety
and efficacy of therapies. However, the vast number of rapidly engineered therapies far outpaces the throughput
of animal-based testing regimes, thus creating a major bottleneck for clinical translation. Leveraging synthetic
biology tools and a high-throughput bacteria-spheroid platform, the objective of this proposal is to rapidly optimize
tumor-homing S. tyhpimurium to express therapeutics locally and specifically in tumors.
Status | Finished |
---|---|
Effective start/end date | 6/15/20 → 9/30/22 |
Funding
- National Institute of Biomedical Imaging and Bioengineering: US$315,756.00
- National Institute of Biomedical Imaging and Bioengineering: US$346,661.00
ASJC Scopus Subject Areas
- Cancer Research
- Oncology
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