Identification of TFAP4 (Transcription Factor Ap-4/activating enhancer binding protein) as a potential master regulator/synthetic lethal gene of mycn amplified neuroblastoma

  • Yamashiro, Darrell (PI)

Project: Research project

Project Details

Description

Amplification of oncogene MYCN is a hallmark of neuroblastoma, and is associated with metastasis and very poor survival. However, despite the identification of MYCN-amplification as an adverse prognostic marker, no drugs that target MYCN have been developed.

StatusActive
Effective start/end date1/1/13 → …

Funding

  • Alex's Lemonade Stand Foundation for Childhood Cancer: US$250,000.00

ASJC Scopus Subject Areas

  • Cancer Research
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)

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