SCAN-MP (Screening for Cardiac Amyloidosiswith Nuclear imaging in Minority Populations)

PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) disproportionately afflicts older Black and Hispanic Americans for which there are no effective medical therapies. Cardiac amyloidosis is a cause of heart failure that we hypothesize is misdiagnosed in 10-15% of elderly patients, potentially comprising up to 500,000 people in the United States. In this application, we propose to recruit a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood tests that we have developed, and to explore differences in genetics and sex as they relate to heart failure disease progression in cardiac amyloidosis.