Project Details
Description
DESCRIPTION (Adapted from investigator's abstract): The overall goal of
this application is targeted methylation of the HIV LTR promoter in a manner
such that HIV transcription is silenced without adverse effects on the host.
This will be achieved not by influencing the affinity of transcriptional
factors for the promoter, but rather the transcribing enzyme, i.e., RNA
polymerase, fails to productively use methylated DNA.
| Status | Finished |
|---|---|
| Effective start/end date | 7/15/96 → 6/30/99 |
Funding
- National Institute of Allergy and Infectious Diseases
ASJC Scopus Subject Areas
- Genetics
- Molecular Biology
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