Project Details
Description
Several recent studies have identified point mutations IDH1 and IDH2 in gliomas. IDH are key enzymes involved in cell metabolism. These mutations occur frequently (50-93%) in diffusely infiltrating astrocytomas and oligodendrogliomas, as well as in some glioblastomas. These studies suggest that IDH1 mutations are an early event in the formation of specific types of diffusely infiltrating gliomas, and this project uses a virus to deliver genes to determine if mutant IDH1 can induce brain tumors in models.
| Status | Finished |
|---|---|
| Effective start/end date | 7/1/11 → 6/30/13 |
Funding
- St. Baldrick's Foundation
ASJC Scopus Subject Areas
- Cancer Research
- Oncology
- Pediatrics, Perinatology, and Child Health
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.