Tau Homeostasis Via Proteasomal and Autophagic Activity

  • Yu, Wai Haung (PI)

Project: Research project

Project Details

Description

Dr. Wai Haung Yu and colleagues will determine how the natural protein recycling systems, called the ubiquitin-proteasome (UPS) and autophagic-lysosome system (A-LS), act in concert to maintain healthy levels and quality of proteins. In Alzheimer's disease (AD), protein clumping is a hallmark that is often accompanied by failure of UPS and A-LS, suggesting that these two recycling pathways are important for disease prevention. Along with improving the understanding of these two mechanisms, these researchers will test drug candidates for enhancement of UPS and A-LS function in reducing tau clumping and for restoring long-lived UPS and A-LS protein recycling activity.
StatusFinished
Effective start/end date7/1/129/30/15

Funding

  • BrightFocus Foundation: US$300,000.00

ASJC Scopus Subject Areas

  • Clinical Neurology
  • Medicine(all)

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