VEGF/KDR Signaling in Airway Epithelial Regeneration and Disease

Project Narrative Mucous metaplasia is commonly seen in acute respiratory illnesses, and is also a characteristic feature of chronic lung diseases including fibrosis, COPD and asthma. Here, we use a combination of mouse models, organoid culture and single-cell analysis to address how abnormal VEGF/KDR signaling contributes to mucous metaplasia. The proposal will provide novel insights into fundamental mechanisms with broad scientific and clinical implications.