Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Daniel Peña-Oyarzun; Roberto Bravo-Sagua; Alexis Diaz-Vega; Larissa Aleman; Mario Chiong; Lorena Garcia; Claudia Bambs; Rodrigo Troncoso; Mariana Cifuentes; Eugenia Morselli; Catterina Ferreccio; Andrew F.G. Quest; Alfredo Criollo; Sergio Lavandero

doi:10.1016/j.freeradbiomed.2018.05.084

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Daniel Peña-Oyarzun, Roberto Bravo-Sagua, Alexis Diaz-Vega, Larissa Aleman, Mario Chiong, Lorena Garcia, Claudia Bambs, Rodrigo Troncoso, Mariana Cifuentes, Eugenia Morselli, Catterina Ferreccio, Andrew F.G. Quest, Alfredo Criollo, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

74 Citations (Scopus)

Abstract

Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.

Original language	English
Pages (from-to)	61-78
Number of pages	18
Journal	Free Radical Biology and Medicine
Volume	124
DOIs	https://doi.org/10.1016/j.freeradbiomed.2018.05.084
Publication status	Published - Aug 20 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Funding

This work was kindly supported by grants from Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT (1171075 to AC, 1160820 to EM, 1150651 to MC, 1161156 to SL and 1140713 to LG); by PIA (ACT172066 to RT, EM and AC), FONDAP (15130011 to MCh, LG, CB, CF, RT, AQ, AC and SL), Convocatoria Nacional de Subvención a Instalación en la Academia (77170004 to RBS), Postdoctoral project (3160226 to RBS), Ph.D. Fellowships Program (21140458 to D.P-O) from the Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) and by the International Centre for Genetic Engineering and Biotechnology, ICGEB, (CRP/CHL16-06 to EM) This work was kindly supported by grants from Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT ( 1171075 to AC, 1160820 to EM, 1150651 to MC, 1161156 to SL and 1140713 to LG); by PIA ( ACT172066 to RT, EM and AC), FONDAP ( 15130011 to MCh, LG, CB, CF, RT, AQ, AC and SL), Convocatoria Nacional de Subvención a Instalación en la Academia ( 77170004 to RBS), Postdoctoral project ( 3160226 to RBS), Ph.D. Fellowships Program ( 21140458 to D.P-O) from the Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) and by the International Centre for Genetic Engineering and Biotechnology, ICGEB , ( CRP/CHL16-06 to EM)

Funders	Funder number
Convocatoria Nacional de Subvención a Instalación en la Academia	3160226, 77170004
PIA	ACT172066
Comisión Nacional de Investigación Científica y Tecnológica	21140458
Fondo Nacional de Desarrollo Científico y Tecnológico	1160820, 1150651, 1171075, 1161156, 1140713
Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias	15130011

ASJC Scopus Subject Areas

Biochemistry
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.freeradbiomed.2018.05.084

Cite this

Peña-Oyarzun, D., Bravo-Sagua, R., Diaz-Vega, A., Aleman, L., Chiong, M., Garcia, L., Bambs, C., Troncoso, R., Cifuentes, M., Morselli, E., Ferreccio, C., Quest, A. F. G., Criollo, A., & Lavandero, S. (2018). Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? Free Radical Biology and Medicine, 124, 61-78. https://doi.org/10.1016/j.freeradbiomed.2018.05.084

Peña-Oyarzun, D, Bravo-Sagua, R, Diaz-Vega, A, Aleman, L, Chiong, M, Garcia, L, Bambs, C, Troncoso, R, Cifuentes, M, Morselli, E, Ferreccio, C, Quest, AFG, Criollo, A & Lavandero, S 2018, 'Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?', Free Radical Biology and Medicine, vol. 124, pp. 61-78. https://doi.org/10.1016/j.freeradbiomed.2018.05.084

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AU - Aleman, Larissa

AU - Chiong, Mario

AU - Garcia, Lorena

AU - Bambs, Claudia

AU - Troncoso, Rodrigo

AU - Cifuentes, Mariana

AU - Morselli, Eugenia

AU - Ferreccio, Catterina

AU - Quest, Andrew F.G.

AU - Criollo, Alfredo

AU - Lavandero, Sergio

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AB - Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases. In this review, we discuss the crosstalk among inflammation, autophagy and oxidative stress, and how they participate in the progression of chronic diseases such as cancer, cardiovascular diseases, obesity and type II diabetes mellitus.

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Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

Access to Document

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Cite this