TY - JOUR
T1 - Autophagy in aging-related oral diseases
AU - Peña-Oyarzún, Daniel
AU - San Martin, Carla
AU - Hernández-Cáceres, María Paz
AU - Lavandero, Sergio
AU - Morselli, Eugenia
AU - Budini, Mauricio
AU - Burgos, Patricia V.
AU - Criollo, Alfredo
N1 - Publisher Copyright:
Copyright © 2022 Peña-Oyarzún, San Martin, Hernández-Cáceres, Lavandero, Morselli, Budini, Burgos and Criollo.
PY - 2022/8/5
Y1 - 2022/8/5
N2 - Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite availability modulating metabolic pathways, differentiation and cell survival. The oral environment is composed of several structures, including mineralized and soft tissues, which are formed by complex interactions between epithelial and mesenchymal cells. With aging, increased prevalence of oral diseases such as periodontitis, oral cancer and periapical lesions are observed in humans. These aging-related oral diseases are chronic conditions that alter the epithelial-mesenchymal homeostasis, disrupting the oral tissue architecture affecting the quality of life of the patients. Given that autophagy levels are reduced with age, the purpose of this review is to discuss the link between autophagy and age-related oral diseases.
AB - Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite availability modulating metabolic pathways, differentiation and cell survival. The oral environment is composed of several structures, including mineralized and soft tissues, which are formed by complex interactions between epithelial and mesenchymal cells. With aging, increased prevalence of oral diseases such as periodontitis, oral cancer and periapical lesions are observed in humans. These aging-related oral diseases are chronic conditions that alter the epithelial-mesenchymal homeostasis, disrupting the oral tissue architecture affecting the quality of life of the patients. Given that autophagy levels are reduced with age, the purpose of this review is to discuss the link between autophagy and age-related oral diseases.
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U2 - 10.3389/fendo.2022.903836
DO - 10.3389/fendo.2022.903836
M3 - Review article
C2 - 35992149
AN - SCOPUS:85136454008
SN - 1664-2392
VL - 13
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 903836
ER -
