Abstract
Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite availability modulating metabolic pathways, differentiation and cell survival. The oral environment is composed of several structures, including mineralized and soft tissues, which are formed by complex interactions between epithelial and mesenchymal cells. With aging, increased prevalence of oral diseases such as periodontitis, oral cancer and periapical lesions are observed in humans. These aging-related oral diseases are chronic conditions that alter the epithelial-mesenchymal homeostasis, disrupting the oral tissue architecture affecting the quality of life of the patients. Given that autophagy levels are reduced with age, the purpose of this review is to discuss the link between autophagy and age-related oral diseases.
| Original language | English |
|---|---|
| Article number | 903836 |
| Journal | Frontiers in Endocrinology |
| Volume | 13 |
| DOIs | |
| Publication status | Published - Aug 5 2022 |
Bibliographical note
Publisher Copyright:Copyright © 2022 Peña-Oyarzún, San Martin, Hernández-Cáceres, Lavandero, Morselli, Budini, Burgos and Criollo.
Funding
This work was supported by the Agencia Nacional de Investigación y Desarrollo de Chile (ANID, Chile): FONDECYT [1200499 to EM and 1211329 to AC]; PIA-ANID [ACT172066 to EM, MB, PB and AC]; FONDAP [15130011 to SL and AC]; FONDECYT Post-doctoral fellowship [3200313 to DP-O and 3210630 to MH-C]; ANID/BASAL/FB210008 and ANID/BASAL/ACE2100099 to PB. Programa de Movilidad Internacional Santander Universidades, Versión 2021 to AC
ASJC Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
