Abstract
A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 622-633 |
| Number of pages | 12 |
| Journal | Clinical Orthopaedics and Related Research |
| Volume | 466 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2008 |
Bibliographical note
Funding Information:One or more of the authors (SAR) has received funding from Wyeth Research, Inc. Each author certifies that his or her institution has approved the animal protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.
Funding
One or more of the authors (SAR) has received funding from Wyeth Research, Inc. Each author certifies that his or her institution has approved the animal protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.
| Funders | Funder number |
|---|---|
| Wyeth Research, Inc. |
ASJC Scopus Subject Areas
- Surgery
- Orthopedics and Sports Medicine