Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity

Harriet S. Gilbert; Henry Ginsberg; Richard Fagerstrom; W. Virgil Brown

doi:10.1016/0002-9343(81)90212-6

Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity

Harriet S. Gilbert, Henry Ginsberg, Richard Fagerstrom, W. Virgil Brown

Vagelos College of Physicians and Surgeons

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Characterization of the hypocholesterolemia observed in polycythemia vera and agnogenic myeloid metaplasia revealed significant reductions in plasma total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in an age- and sex-matched comparison with the Framingham population. Men with myeloproliferative disease also had significantly lower total and LDL cholesterol levels than did those with relative or secondary polycythemia. LDL and HDL cholesterol were significantly correlated, suggesting a generalized disturbance of cholesterol metabolism, unexplained by nutritional status. Evaluation of the relationship among hematic cell proliferation, degree of myeloid metaplasia and hypocholesterolemia by multiple regression analysis revealed that spleen size was the variable of most significance in explaining the variation in plasma total, LDL and HDL cholesterol levels. Uncontrolled disease activity was accompanied by a decline in LDL cholesterol levels. Splenectomy or control of proliferation with chemotherapy or splenic irradiation reversed this abnormality. Levels of plasma total and lipoprotein cholesterol provide information that may be of value in diagnosis and assessment of myeloproliferative disease activity.

Original language	English
Pages (from-to)	595-602
Number of pages	8
Journal	American Journal of Medicine
Volume	71
Issue number	4
DOIs	https://doi.org/10.1016/0002-9343(81)90212-6
Publication status	Published - Oct 1981

Bibliographical note

Funding Information:
From the Departments of Medicine and Biosta- tistics. Mount Sinai Medical Center, Mount Sinai School of Medicine of City University of New York, New York, New York. This work was supported in part by NIH &ant 1 ROl HL 23077 from the NHLBI, by NIH Grant RR-71. Division of Research Resources, General Clinical Research Centers Branch, and by the Jack Martin f%nd. Dr. Ginsberg is the Schwartz Scholar of the Brookdale Foundation. Reprint requests should be addressed to Dr. Harriet S. Gilbert, Mount Sinai School of Medicine, 19 East 98th Street, New York, NY 10029. Manuscript accepted April 27, 1981.

ASJC Scopus Subject Areas

General Medicine

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title = "Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity",

abstract = "Characterization of the hypocholesterolemia observed in polycythemia vera and agnogenic myeloid metaplasia revealed significant reductions in plasma total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in an age- and sex-matched comparison with the Framingham population. Men with myeloproliferative disease also had significantly lower total and LDL cholesterol levels than did those with relative or secondary polycythemia. LDL and HDL cholesterol were significantly correlated, suggesting a generalized disturbance of cholesterol metabolism, unexplained by nutritional status. Evaluation of the relationship among hematic cell proliferation, degree of myeloid metaplasia and hypocholesterolemia by multiple regression analysis revealed that spleen size was the variable of most significance in explaining the variation in plasma total, LDL and HDL cholesterol levels. Uncontrolled disease activity was accompanied by a decline in LDL cholesterol levels. Splenectomy or control of proliferation with chemotherapy or splenic irradiation reversed this abnormality. Levels of plasma total and lipoprotein cholesterol provide information that may be of value in diagnosis and assessment of myeloproliferative disease activity.",

author = "Gilbert, {Harriet S.} and Henry Ginsberg and Richard Fagerstrom and Brown, {W. Virgil}",

note = "Funding Information: From the Departments of Medicine and Biosta- tistics. Mount Sinai Medical Center, Mount Sinai School of Medicine of City University of New York, New York, New York. This work was supported in part by NIH &ant 1 ROl HL 23077 from the NHLBI, by NIH Grant RR-71. Division of Research Resources, General Clinical Research Centers Branch, and by the Jack Martin f%nd. Dr. Ginsberg is the Schwartz Scholar of the Brookdale Foundation. Reprint requests should be addressed to Dr. Harriet S. Gilbert, Mount Sinai School of Medicine, 19 East 98th Street, New York, NY 10029. Manuscript accepted April 27, 1981.",

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N1 - Funding Information: From the Departments of Medicine and Biosta- tistics. Mount Sinai Medical Center, Mount Sinai School of Medicine of City University of New York, New York, New York. This work was supported in part by NIH &ant 1 ROl HL 23077 from the NHLBI, by NIH Grant RR-71. Division of Research Resources, General Clinical Research Centers Branch, and by the Jack Martin f%nd. Dr. Ginsberg is the Schwartz Scholar of the Brookdale Foundation. Reprint requests should be addressed to Dr. Harriet S. Gilbert, Mount Sinai School of Medicine, 19 East 98th Street, New York, NY 10029. Manuscript accepted April 27, 1981.

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N2 - Characterization of the hypocholesterolemia observed in polycythemia vera and agnogenic myeloid metaplasia revealed significant reductions in plasma total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in an age- and sex-matched comparison with the Framingham population. Men with myeloproliferative disease also had significantly lower total and LDL cholesterol levels than did those with relative or secondary polycythemia. LDL and HDL cholesterol were significantly correlated, suggesting a generalized disturbance of cholesterol metabolism, unexplained by nutritional status. Evaluation of the relationship among hematic cell proliferation, degree of myeloid metaplasia and hypocholesterolemia by multiple regression analysis revealed that spleen size was the variable of most significance in explaining the variation in plasma total, LDL and HDL cholesterol levels. Uncontrolled disease activity was accompanied by a decline in LDL cholesterol levels. Splenectomy or control of proliferation with chemotherapy or splenic irradiation reversed this abnormality. Levels of plasma total and lipoprotein cholesterol provide information that may be of value in diagnosis and assessment of myeloproliferative disease activity.

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Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity

Abstract

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