TY - JOUR
T1 - Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe 2+
AU - García-Beltrán, Olimpo
AU - Mena, Natalia
AU - Yañez, Osvaldo
AU - Caballero, Julio
AU - Vargas, Víctor
AU - Nuñez, Marco T.
AU - Cassels, Bruce K.
PY - 2013
Y1 - 2013
N2 - A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3- dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe 2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties.
AB - A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3- dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe 2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties.
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U2 - 10.1016/j.ejmech.2013.06.022
DO - 10.1016/j.ejmech.2013.06.022
M3 - Article
C2 - 23835483
AN - SCOPUS:84880181997
SN - 0223-5234
VL - 67
SP - 60
EP - 63
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -