Abstract
The incidence and prevalence of diabetes mellitus are each increasing rapidly in our society. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease, a process termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process characterized by significant changes in the physiology, structure, and mechanical function of the heart. Here, we review recently derived insights into mechanisms and molecular events involved in the pathogenesis of diabetic cardiomyopathy.
| Original language | English |
|---|---|
| Pages (from-to) | e135-e143 |
| Journal | Drug Discovery Today: Disease Mechanisms |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2010 |
Bibliographical note
Funding Information:This work was supported by grants from the NIH (HL-075173, JAH; HL-080144, JAH; HL-090842, JAH), AHA (0640084N, JAH), ADA (7-08-MN-21-ADA, JAH), the AHA-Jon Holden DeHaan Foundation (0970518N, JAH), and the Fondo Nacional de Desarrollo Cientifico y Tecnologico : FONDECYT 1080436 and FONDAP 15010006 (SL).
Funding
This work was supported by grants from the NIH (HL-075173, JAH; HL-080144, JAH; HL-090842, JAH), AHA (0640084N, JAH), ADA (7-08-MN-21-ADA, JAH), the AHA-Jon Holden DeHaan Foundation (0970518N, JAH), and the Fondo Nacional de Desarrollo Cientifico y Tecnologico : FONDECYT 1080436 and FONDAP 15010006 (SL).
| Funders | Funder number |
|---|---|
| AHA-Jon Holden DeHaan Foundation | 0970518N |
| National Institutes of Health | HL-075173, HL-080144, HL-090842 |
| American Heart Association | 0640084N |
| Fondo Nacional de Desarrollo Científico y Tecnológico | 1080436, FONDAP 15010006 |
| Aeronautical Development Agency |
ASJC Scopus Subject Areas
- Molecular Medicine
- Drug Discovery
