Terry, M. B., Michels, K. B., Brody, J. G., Byrne, C., Chen, S., Jerry, D. J., Malecki, K. M. C., Martin, M. B., Miller, R. L., Neuhausen, S. L., Silk, K., Trentham-Dietz, A., McDonald, J., Oskar, S., Knight, J., Toro-Campos, R., Cai, X., Rising, C. J., Afanaseva, D., ... Fisher, C. (2019). Environmental exposures during windows of susceptibility for breast cancer: A framework for prevention research. Breast Cancer Research, 21(1), Article 96. https://doi.org/10.1186/s13058-019-1168-2
Terry, MB, Michels, KB, Brody, JG, Byrne, C, Chen, S, Jerry, DJ, Malecki, KMC, Martin, MB, Miller, RL, Neuhausen, SL, Silk, K, Trentham-Dietz, A, McDonald, J, Oskar, S, Knight, J, Toro-Campos, R, Cai, X, Rising, CJ, Afanaseva, D, Mullis, MD, Berry, MP, Bird, J, Bradfield, C, Gangnon, R, Gould, M, Hampton, J, Lindberg, S, Luongo, S, Rolland, B, Shull, J, Gaudet, M, Thornquist, M, Aupperlee, MD, Haslam, SZ, Hoshyar, R, Kariagina, A, Lopes, JR, Miller, KJ, Morozova, O, Newkirk, CJ, Schwartz, RC, Thomas, B, Totzkay, D, Xie, F, Silk, KJ, Biro, FM, Fassler, CS, Giannini, CM, Pinney, S, Troester, MA, Burke, K, Herbstman, J, Kehm, R, Lilge, L, Perera, F, Sahay, D, Tehranifar, P, Walker, D, Zeinomar, N, De Hoz, M, Shepard, P, Binder, A, Bessonneau, V, De La Rosa, V, Ohayon, J, Rudel, R, Corvalan, C, Pereira, A, Pereira, J, Russo, J, Yanrong, S, Shepherd, J, Adams-Campbell, L, Dash, C, Haddad, B, Hamilton, R, Richardson, B, Denic-Roberts, H, Chang, G, Ding, YC, Kanaya, N, Rakoff, M, Saeki, K, Serrano, M, Reynolds, P, Dunphy, K, Jerry, J, Symington, A, Vandenberg, L, Schneider, S, Adams, SA, Brandt, HM, Friedman, D, Lead, JR, Kreps, G, Wright, K, Burke-Garcia, A & Fisher, C 2019, 'Environmental exposures during windows of susceptibility for breast cancer: A framework for prevention research', Breast Cancer Research, vol. 21, no. 1, 96. https://doi.org/10.1186/s13058-019-1168-2
TY - JOUR
T1 - Environmental exposures during windows of susceptibility for breast cancer
T2 - A framework for prevention research
AU - Terry, Mary Beth
AU - Michels, Karin B.
AU - Brody, Julia Green
AU - Byrne, Celia
AU - Chen, Shiuan
AU - Jerry, D. Joseph
AU - Malecki, Kristen M.C.
AU - Martin, Mary Beth
AU - Miller, Rachel L.
AU - Neuhausen, Susan L.
AU - Silk, Kami
AU - Trentham-Dietz, Amy
AU - McDonald, Jasmine
AU - Oskar, Sabine
AU - Knight, Julia
AU - Toro-Campos, Rosario
AU - Cai, Xiaomei
AU - Rising, Camella J.
AU - Afanaseva, Dasha
AU - Mullis, Michaela Devyn
AU - Berry, Mary Pat
AU - Bird, Jennifer
AU - Bradfield, Christopher
AU - Gangnon, Ronald
AU - Gould, Michael
AU - Hampton, John
AU - Lindberg, Sara
AU - Luongo, Sarah
AU - Rolland, Betsy
AU - Shull, James
AU - Gaudet, Mia
AU - Thornquist, Mark
AU - Aupperlee, Mark D.
AU - Haslam, Sandra Z.
AU - Hoshyar, Reyhane
AU - Kariagina, Anastasia
AU - Lopes, Juliana R.
AU - Miller, Karen J.
AU - Morozova, Olena
AU - Newkirk, Cathy J.
AU - Schwartz, Richard C.
AU - Thomas, Brandon
AU - Totzkay, Daniel
AU - Xie, Fang
AU - Silk, Kami J.
AU - Biro, Frank M.
AU - Fassler, Cecily S.
AU - Giannini, Courtney M.
AU - Pinney, Susan
AU - Troester, Melissa A.
AU - Burke, Kimberly
AU - Herbstman, Julie
AU - Kehm, Rebecca
AU - Lilge, Logthar
AU - Perera, Frederica
AU - Sahay, Debeshish
AU - Tehranifar, Parisa
AU - Walker, Desiree
AU - Zeinomar, Nur
AU - De Hoz, Milagros
AU - Shepard, Peggy
AU - Binder, Alexandra
AU - Bessonneau, Vincent
AU - De La Rosa, Vanessa
AU - Ohayon, Jennifer
AU - Rudel, Ruthann
AU - Corvalan, Camila
AU - Pereira, Ana
AU - Pereira, Julia
AU - Russo, Jose
AU - Yanrong, Su
AU - Shepherd, John
AU - Adams-Campbell, Lucile
AU - Dash, Chiranjeev
AU - Haddad, Bassem
AU - Hamilton, Rhonda
AU - Richardson, Brenda
AU - Denic-Roberts, Hristina
AU - Chang, Gregory
AU - Ding, Yuan Chun
AU - Kanaya, Noriko
AU - Rakoff, Michele
AU - Saeki, Kohei
AU - Serrano, Mayra
AU - Reynolds, Peggy
AU - Dunphy, Karen
AU - Jerry, Joseph
AU - Symington, Anna
AU - Vandenberg, Laura
AU - Schneider, Sallie
AU - Adams, Swann Arp
AU - Brandt, Heather M.
AU - Friedman, Daniela
AU - Lead, Jamie R.
AU - Kreps, Gary
AU - Wright, Kevin
AU - Burke-Garcia, Amelia
AU - Fisher, Carla
N1 - Publisher Copyright:
© 2019 The Author(s).
PY - 2019/8/20
Y1 - 2019/8/20
N2 - Background: The long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. The influence of environmental chemicals on breast cancer risk may be greater during several windows of susceptibility (WOS) in a woman's life, including prenatal development, puberty, pregnancy, and the menopausal transition. These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. Breast cancer research focused on these breast cancer WOS will accelerate understanding of disease etiology and prevention. Main text: Despite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland's structure and function, most human studies of environmental chemicals are not focused on specific WOS. This article reviews studies conducted over the past few decades that have specifically addressed the effect of environmental chemicals and metals on breast cancer risk during at least one of these WOS. In addition to summarizing the broader evidence-base specific to WOS, we include discussion of the NIH-funded Breast Cancer and the Environment Research Program (BCERP) which included population-based and basic science research focused on specific WOS to evaluate associations between breast cancer risk and particular classes of endocrine-disrupting chemicals - including polycyclic aromatic hydrocarbons, perfluorinated compounds, polybrominated diphenyl ethers, and phenols - and metals. We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers. Conclusions: An integrative model of breast cancer research is needed to determine the impact and mechanisms of action of endocrine disruptors at different WOS. By focusing on environmental chemical exposure during specific WOS, scientists and their community partners may identify when prevention efforts are likely to be most effective.
AB - Background: The long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. The influence of environmental chemicals on breast cancer risk may be greater during several windows of susceptibility (WOS) in a woman's life, including prenatal development, puberty, pregnancy, and the menopausal transition. These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. Breast cancer research focused on these breast cancer WOS will accelerate understanding of disease etiology and prevention. Main text: Despite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland's structure and function, most human studies of environmental chemicals are not focused on specific WOS. This article reviews studies conducted over the past few decades that have specifically addressed the effect of environmental chemicals and metals on breast cancer risk during at least one of these WOS. In addition to summarizing the broader evidence-base specific to WOS, we include discussion of the NIH-funded Breast Cancer and the Environment Research Program (BCERP) which included population-based and basic science research focused on specific WOS to evaluate associations between breast cancer risk and particular classes of endocrine-disrupting chemicals - including polycyclic aromatic hydrocarbons, perfluorinated compounds, polybrominated diphenyl ethers, and phenols - and metals. We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers. Conclusions: An integrative model of breast cancer research is needed to determine the impact and mechanisms of action of endocrine disruptors at different WOS. By focusing on environmental chemical exposure during specific WOS, scientists and their community partners may identify when prevention efforts are likely to be most effective.
UR - http://www.scopus.com/inward/record.url?scp=85071032516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071032516&partnerID=8YFLogxK
U2 - 10.1186/s13058-019-1168-2
DO - 10.1186/s13058-019-1168-2
M3 - Review article
C2 - 31429809
AN - SCOPUS:85071032516
SN - 1465-5411
VL - 21
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - 96
ER -
