Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas

Translated title of the contribution: Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives

Rodrigo Miranda H, Pablo Castro G, Hugo Verdejo P, Mario Chiong, Guillermo Díaz-Araya, Rosemarie Mellado, Diego Rojas, Roberto Concepción, Sergio Lavandero

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a higher generation of reactive oxygen species. This phenomenon, along with pro-inflammatory cytokine activation and extra cellular matrix alterations with reactive fibrosis, play an important role in the pathogenesis and progression of heart failure, through the development of endothelial and myocardial dysfunction. The understanding of the underlying phenomena and the metabolic pathways involved will allow further development of therapies aiming to change the natural history of heart failure.

Translated title of the contributionOxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives
Original languageSpanish
Pages (from-to)1056-1063
Number of pages8
JournalRevista Medica de Chile
Volume135
Issue number8
Publication statusPublished - Aug 2007

ASJC Scopus Subject Areas

  • General Medicine

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