Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative response to carvedilol

Rodrigo Troncoso, Francisco Moraga, Mario Chiong, Juan Roldán, Roberto Bravo, Rodrigo Valenzuela, Guillermo Díaz-Araya, Andrea Del Campo, Carlos Sanhueza, Andrea Rodriguez, José Luis Vukasovic, Rosemarie Mellado, Douglas Greig, Pablo F. Castro, Sergio Lavandero

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln27→Gluβ2-adrenergic receptor polymorphism. Carvedilol significantly increased the left ventricular ejection fraction, while decreasing the heart rate and malondialdehyde plasma concentrations in chronic heart failure patients with the Glu 27β2-adrenergic receptor allele. There were however, no significant changes in patients with the Gln27β2- adrenergic receptor variant.

Original languageEnglish
Pages (from-to)374-378
Number of pages5
JournalBasic and Clinical Pharmacology and Toxicology
Volume104
Issue number5
DOIs
Publication statusPublished - May 2009

ASJC Scopus Subject Areas

  • Toxicology
  • Pharmacology

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Troncoso, R., Moraga, F., Chiong, M., Roldán, J., Bravo, R., Valenzuela, R., Díaz-Araya, G., Del Campo, A., Sanhueza, C., Rodriguez, A., Vukasovic, J. L., Mellado, R., Greig, D., Castro, P. F., & Lavandero, S. (2009). Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative response to carvedilol. Basic and Clinical Pharmacology and Toxicology, 104(5), 374-378. https://doi.org/10.1111/j.1742-7843.2008.00370.x