H215O PET study of impairment of nonverbal recognition with normal aging

Karen E. Anderson; Katherine Lynch; Eric Zarahn; Nick Scarmeas; Ronald Van Heertum; Harold Sackeim; James R. Moeller; Yaakov Stern

doi:10.1176/jnp.17.2.192

H₂¹⁵O PET study of impairment of nonverbal recognition with normal aging

Karen E. Anderson, Katherine Lynch, Eric Zarahn, Nick Scarmeas, Ronald Van Heertum, Harold Sackeim, James R. Moeller, Yaakov Stern

Vagelos College of Physicians and Surgeons

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Little research has been conducted regarding age-related changes in nonverbal memory. Using positron emission tomography (PET), the authors studied 17 elderly volunteers and 20 young volunteers, during nonverbal recognition task performance, to examine differences in brain blood flow. The subjects were asked to recognize a study list size (SLS) of shapes that was adjusted so that each subject performed at approximately 75% accuracy. Positron emission tomography results showed that, relative to younger individuals, elderly subjects engaged different regions, including the insula, during recognition. Elderly subjects did not show the relationship between parahippocampal flow and SLS, which was observed in younger subjects. These differences suggest that age-related functional brain changes partly explain performance deficits.

Original language	English
Pages (from-to)	192-200
Number of pages	9
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	17
Issue number	2
DOIs	https://doi.org/10.1176/jnp.17.2.192
Publication status	Published - 2005

Funding

Funders	Funder number
National Institute on Aging	R01AG014671

ASJC Scopus Subject Areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1176/jnp.17.2.192

Cite this

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abstract = "Little research has been conducted regarding age-related changes in nonverbal memory. Using positron emission tomography (PET), the authors studied 17 elderly volunteers and 20 young volunteers, during nonverbal recognition task performance, to examine differences in brain blood flow. The subjects were asked to recognize a study list size (SLS) of shapes that was adjusted so that each subject performed at approximately 75% accuracy. Positron emission tomography results showed that, relative to younger individuals, elderly subjects engaged different regions, including the insula, during recognition. Elderly subjects did not show the relationship between parahippocampal flow and SLS, which was observed in younger subjects. These differences suggest that age-related functional brain changes partly explain performance deficits.",

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AU - Anderson, Karen E.

AU - Lynch, Katherine

AU - Zarahn, Eric

AU - Scarmeas, Nick

AU - Van Heertum, Ronald

AU - Sackeim, Harold

AU - Moeller, James R.

AU - Stern, Yaakov

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