Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

of program collaborators for Environmental influences on Child Health Outcomes

doi:10.1016/j.jaci.2023.03.016

Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

of program collaborators for Environmental influences on Child Health Outcomes

Mailman School of Public Health

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.

Original language	English
Pages (from-to)	84-93
Number of pages	10
Journal	Journal of Allergy and Clinical Immunology
Volume	152
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2023.03.016
Publication status	Published - Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 American Academy of Allergy, Asthma & Immunology

Funding

Research reported in this presentation was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under ECHO components U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with cofunding from the Office of Behavioral and Social Science Research (PRO Core), UH3OD023251 (A. Alshawabkeh), UH3OD023320 (J. Aschner), UH3OD023332 (L. Trasande), UH3OD023253 (C.A.C.), UH3OD023248 (D.M.D.), UH3OD023313 (S. Deoni), UH3OD023328 (C. Duarte), UH3OD023318 (A. Dunlop), UH3OD023279 (A. Elliott), UH3OD023289 (A.F.), UH3OD023282 (J.E.G.), UH3OD023287 (C.B.), UH3OD023365 (I. Hertz-Picciotto), UH3OD023244 (A. Hipwell), UH3OD023275 (M. Karagas), UH3OD023271 (C. Karr), UH3OD023347 (B. Lester), UH3OD023389 (L. Leve), UH3OD023268 (S. Weiss), UH3OD023288 (C. McE.), UH3OD023342 (K. Lyall), UH3OD023286 (E.O.), UH3OD023348 (O'Shea), UH3OD023285 (J.M.K.), UH3OD023290 (J. Herbstman) UH3OD023272 (S. Schantz), UH3OD023249 (J.B.S.), and UH3OD023337 (R.J.W.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.Disclosure of potential conflict of interest: C.A. Camargo, Jr, served on Scientific Advisory Boards for AstraZeneca (in 2020) and Sanofi Genzyme (in 2021). J.F. Cordero is a consultant to Sanofi Pasteur specifically about dengue vaccine development. J.E. Gern has received consulting fees from AstraZeneca and Meissa Vaccines, Inc, and has stock options in Meissa Vaccines, Inc. T. Hartert serves on vaccine Data and Safety Monitoring Boards and advisory panels for Pfizer and Sanofi (without funding). D.J. Jackson has received funding from GlaxoSmithKline and Regeneron; personal fees for Data and Safety Monitoring Board from Pfizer; and personal fees for consulting from AstraZeneca, Avillion, GlaxoSmithKline, Sanofi, and Regeneron. The rest of the authors declare that they have no relevant conflicts of interest. Research reported in this presentation was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of the Director , National Institutes of Health, under ECHO components U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with cofunding from the Office of Behavioral and Social Science Research (PRO Core), UH3OD023251 (A. Alshawabkeh), UH3OD023320 (J. Aschner), UH3OD023332 (L. Trasande), UH3OD023253 (C.A.C.), UH3OD023248 (D.M.D.), UH3OD023313 (S. Deoni), UH3OD023328 (C. Duarte), UH3OD023318 (A. Dunlop), UH3OD023279 (A. Elliott), UH3OD023289 (A.F.), UH3OD023282 (J.E.G.), UH3OD023287 (C.B.), UH3OD023365 (I. Hertz-Picciotto), UH3OD023244 (A. Hipwell), UH3OD023275 (M. Karagas), UH3OD023271 (C. Karr), UH3OD023347 (B. Lester), UH3OD023389 (L. Leve), UH3OD023268 (S. Weiss), UH3OD023288 (C. McE.), UH3OD023342 (K. Lyall), UH3OD023286 (E.O.), UH3OD023348 (O’Shea), UH3OD023285 (J.M.K.), UH3OD023290 (J. Herbstman) UH3OD023272 (S. Schantz), UH3OD023249 (J.B.S.), and UH3OD023337 (R.J.W.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Disclosure of potential conflict of interest: C.A. Camargo, Jr, served on Scientific Advisory Boards for AstraZeneca (in 2020) and Sanofi Genzyme (in 2021). J.F. Cordero is a consultant to Sanofi Pasteur specifically about dengue vaccine development. J.E. Gern has received consulting fees from AstraZeneca and Meissa Vaccines, Inc, and has stock options in Meissa Vaccines, Inc. T. Hartert serves on vaccine Data and Safety Monitoring Boards and advisory panels for Pfizer and Sanofi (without funding). D.J. Jackson has received funding from GlaxoSmithKline and Regeneron; personal fees for Data and Safety Monitoring Board from Pfizer; and personal fees for consulting from AstraZeneca , Avillion, GlaxoSmithKline , Sanofi , and Regeneron . The rest of the authors declare that they have no relevant conflicts of interest.

Funders	Funder number
Pfizer and Sanofi
Sanofi Pasteur specifically about dengue vaccine development
National Institutes of Health	UH3OD023318, UH3OD023337, UH3OD023313, UH3OD023279, UH3OD023332, UH3OD023253, UH3OD023275, UH3OD023251, UH3OD023272, UH3OD023271, UH3OD023290, U24OD023382, UH3OD023328, UH3OD023249, UH3OD023348, U24OD023319, UH3OD023248, UH3OD023347, UH3OD023268, UH3OD023389, UH3OD023289, UH3OD023244, UH3OD023288, UH3OD023365, UH3OD023287, UH3OD023320, UH3OD023342, UH3OD023286, UH3OD023285, U2COD023375, UH3OD023282
Office of the Director
GlaxoSmithKline
Sanofi

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2023.03.016

Cite this

Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program. / of program collaborators for Environmental influences on Child Health Outcomes.
In: Journal of Allergy and Clinical Immunology, Vol. 152, No. 1, 07.2023, p. 84-93.

Research output: Contribution to journal › Article › peer-review

@article{d836bac32a19485daa292d1b78b14d24,

title = "Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program",

abstract = "Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.",

author = "{of program collaborators for Environmental influences on Child Health Outcomes} and Miller, {Rachel L.} and Holly Schuh and Aruna Chandran and Aris, {Izzuddin M.} and Casper Bendixsen and Jeffrey Blossom and Carrie Breton and Camargo, {Carlos A.} and Glorisa Canino and Carroll, {Kecia N.} and Sarah Commodore and Cordero, {Jos{\'e} F.} and Dabelea, {Dana M.} and Assiamira Ferrara and Fry, {Rebecca C.} and Ganiban, {Jody M.} and Gern, {James E.} and Gilliland, {Frank D.} and Gold, {Diane R.} and Rima Habre and Hare, {Marion E.} and Harte, {Robyn N.} and Tina Hartert and Kohei Hasegawa and {Khurana Hershey}, {Gurjit K.} and Jackson, {Daniel J.} and Christine Joseph and Kerver, {Jean M.} and Haejin Kim and Litonjua, {Augusto A.} and Marsit, {Carmen J.} and Cindy McEvoy and Mendon{\c c}a, {Eneida A.} and Moore, {Paul E.} and Nkoy, {Flory L.} and O'Connor, {Thomas G.} and Emily Oken and Dennis Ownby and Matthew Perzanowski and Katherine Rivera-Spoljaric and Ryan, {Patrick H.} and Singh, {Anne Marie} and Stanford, {Joseph B.} and Wright, {Rosalind J.} and Wright, {Robert O.} and Antonella Zanobetti and Edward Zoratti and Johnson, {Christine C.} and Smith, {P. B.} and J. Herbstman",

note = "Publisher Copyright: {\textcopyright} 2023 American Academy of Allergy, Asthma & Immunology",

year = "2023",

month = jul,

doi = "10.1016/j.jaci.2023.03.016",

language = "English",

volume = "152",

pages = "84--93",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

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TY - JOUR

T1 - Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

AU - of program collaborators for Environmental influences on Child Health Outcomes

AU - Miller, Rachel L.

AU - Schuh, Holly

AU - Chandran, Aruna

AU - Aris, Izzuddin M.

AU - Bendixsen, Casper

AU - Blossom, Jeffrey

AU - Breton, Carrie

AU - Camargo, Carlos A.

AU - Canino, Glorisa

AU - Carroll, Kecia N.

AU - Commodore, Sarah

AU - Cordero, José F.

AU - Dabelea, Dana M.

AU - Ferrara, Assiamira

AU - Fry, Rebecca C.

AU - Ganiban, Jody M.

AU - Gern, James E.

AU - Gilliland, Frank D.

AU - Gold, Diane R.

AU - Habre, Rima

AU - Hare, Marion E.

AU - Harte, Robyn N.

AU - Hartert, Tina

AU - Hasegawa, Kohei

AU - Khurana Hershey, Gurjit K.

AU - Jackson, Daniel J.

AU - Joseph, Christine

AU - Kerver, Jean M.

AU - Kim, Haejin

AU - Litonjua, Augusto A.

AU - Marsit, Carmen J.

AU - McEvoy, Cindy

AU - Mendonça, Eneida A.

AU - Moore, Paul E.

AU - Nkoy, Flory L.

AU - O'Connor, Thomas G.

AU - Oken, Emily

AU - Ownby, Dennis

AU - Perzanowski, Matthew

AU - Rivera-Spoljaric, Katherine

AU - Ryan, Patrick H.

AU - Singh, Anne Marie

AU - Stanford, Joseph B.

AU - Wright, Rosalind J.

AU - Wright, Robert O.

AU - Zanobetti, Antonella

AU - Zoratti, Edward

AU - Johnson, Christine C.

AU - Smith, P. B.

AU - Herbstman, J.

PY - 2023/7

Y1 - 2023/7

N2 - Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.

AB - Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.

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Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

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