Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches

Julian Bejarano; Mario Navarro-Marquez; Francisco Morales-Zavala; Javier O. Morales; Ivonne Garcia-Carvajal; Eyleen Araya-Fuentes; Yvo Flores; Hugo E. Verdejo; Pablo F. Castro; Sergio Lavandero; Marcelo J. Kogan

doi:10.7150/thno.26284

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches

Julian Bejarano, Mario Navarro-Marquez, Francisco Morales-Zavala, Javier O. Morales, Ivonne Garcia-Carvajal, Eyleen Araya-Fuentes, Yvo Flores, Hugo E. Verdejo, Pablo F. Castro, Sergio Lavandero, Marcelo J. Kogan

Universidad de Chile

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Abstract

Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying cardiovascular diseases remains elusive, and overt coronary artery disease or myocardial infarction is often the first clinical manifestation. Nanoparticles represent a novel strategy for prevention, diagnosis, and treatment of atherosclerosis, and new multifunctional nanoparticles with combined diagnostic and therapeutic capacities hold the promise for theranostic approaches to this disease. This review focuses on the development of nanosystems for therapy and diagnosis of subclinical atherosclerosis, coronary artery disease, and myocardial infarction and the evolution of nanosystems as theranostic tools. We also discuss the use of nanoparticles in noninvasive imaging, targeted drug delivery, photothermal therapies together with the challenges faced by nanosystems during clinical translation.

Original language	English
Pages (from-to)	4710-4732
Number of pages	23
Journal	Theranostics
Volume	8
Issue number	17
DOIs	https://doi.org/10.7150/thno.26284
Publication status	Published - 2018

Bibliographical note

Publisher Copyright:
© Ivyspring International Publisher.

Funding

This work was supported by Comisión Nacional de Investigación Científica y Tecnológica (CONICYT), Chile, Fondo de Financiamiento Centros de Excelencia en Investigación en Áreas Prioritarias (FONDAP) grant 15130011 (to. S.L., M.K., P.F.C., H.E.V. F.M.Z and J.O.M) and Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) grants 1170929 (to M.K.) and 1181689 (to J.O.M). J.B. was supported by post-doctoral FONDECYT grants 3160323. M.N-M and I.G-C are recipients of a Ph.D. fellowship from CONICYT. EA acknowledges Proyecto Nucleo DI-36-18/N.

Funders	Funder number
Comisión Nacional de Investigación Científica y Tecnológica
Fondo Nacional de Desarrollo Científico y Tecnológico	3160323
Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias	15130011

ASJC Scopus Subject Areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Bejarano, J., Navarro-Marquez, M., Morales-Zavala, F., Morales, J. O., Garcia-Carvajal, I., Araya-Fuentes, E., Flores, Y., Verdejo, H. E., Castro, P. F., Lavandero, S., & Kogan, M. J. (2018). Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches. Theranostics, 8(17), 4710-4732. https://doi.org/10.7150/thno.26284

Bejarano, J, Navarro-Marquez, M, Morales-Zavala, F, Morales, JO, Garcia-Carvajal, I, Araya-Fuentes, E, Flores, Y, Verdejo, HE, Castro, PF, Lavandero, S & Kogan, MJ 2018, 'Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches', Theranostics, vol. 8, no. 17, pp. 4710-4732. https://doi.org/10.7150/thno.26284

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Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: Evolution toward prospective theranostic approaches

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

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