Reichler, M. R., Hirsch, C., Yuan, Y., Khan, A., Dorman, S. E., Schluger, N., Sterling, T. R., Bakhtawar, I., Ledoux, C., McAuley, J., Beison, J., Fitzgerald, M., Naus, M., Nakajima, M., Schluger, N., Hirsch-Moverman, Y., Moran, J., Blumberg, H., Tapia, J., ... Luo, C. (2020). Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada. BMC Infectious Diseases, 20(1), Article 553. https://doi.org/10.1186/s12879-020-05185-2
Reichler, MR, Hirsch, C, Yuan, Y, Khan, A, Dorman, SE, Schluger, N, Sterling, TR, Bakhtawar, I, Ledoux, C, McAuley, J, Beison, J, Fitzgerald, M, Naus, M, Nakajima, M, Schluger, N, Hirsch-Moverman, Y, Moran, J, Blumberg, H, Tapia, J, Singha, L, Hershfeld, E, Roche, B, Mangura, B, Sevilla, A, Chavez-Lindell, T, Maruri, F, Dorman, S, Cronin, W, Munk, E, Khan, A, Yuan, Y, Chen, B, Yan, F, Shen, Y, Zhao, H, Zhang, H, Bessler, P, Fagley, M, Reichler, M, Tapia, J, Hirsch, C & Luo, C 2020, 'Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada', BMC Infectious Diseases, vol. 20, no. 1, 553. https://doi.org/10.1186/s12879-020-05185-2
@article{f9a0ce0c297440a69237e7487010cfaf,
title = "Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada",
abstract = "Background: We examined cytokine immune response profiles among contacts to tuberculosis patients to identify immunologic and epidemiologic correlates of tuberculosis. Methods: We prospectively enrolled 1272 contacts of culture-confirmed pulmonary tuberculosis patients at 9 United States and Canadian sites. Epidemiologic characteristics were recorded. Blood was collected and stimulated with Mycobacterium tuberculosis culture filtrate protein, and tumor necrosis factor (TNF-α), interferon gamma (IFN-γ), and interleukin 10 (IL-10) concentrations were determined using immunoassays. Results: Of 1272 contacts, 41 (3.2%) were diagnosed with tuberculosis before or < 30 days after blood collection (co-prevalent tuberculosis) and 19 (1.5%) during subsequent four-year follow-up (incident tuberculosis). Compared with contacts without tuberculosis, those with co-prevalent tuberculosis had higher median baseline TNF-α and IFN-γconcentrations (in pg/mL, TNF-α 129 versus 71, P <.01; IFN-γ231 versus 27, P <.001), and those who subsequently developed incident tuberculosis had higher median baseline TNF-α concentrations (in pg/mL, 257 vs. 71, P <.05). In multivariate analysis, contact age < 15 years, US/Canadian birth, and IFN or TNF concentrations > the median were associated with co-prevalent tuberculosis (P <.01 for each); female sex (P =.03) and smoking (P <.01) were associated with incident tuberculosis. In algorithms combining young age, positive skin test results, and elevated CFPS TNF-α, IFN-γ, and IL-10 responses, the positive predictive values for co-prevalent and incident tuberculosis were 40 and 25%, respectively. Conclusions: Cytokine concentrations and epidemiologic factors at the time of contact investigation may predict co-prevalent and incident tuberculosis.",
author = "Reichler, {Mary R.} and Christina Hirsch and Yan Yuan and Awal Khan and Dorman, {Susan E.} and Neil Schluger and Sterling, {Timothy R.} and I. Bakhtawar and C. Ledoux and J. McAuley and J. Beison and M. Fitzgerald and M. Naus and M. Nakajima and N. Schluger and Y. Hirsch-Moverman and J. Moran and H. Blumberg and J. Tapia and L. Singha and E. Hershfeld and B. Roche and B. Mangura and A. Sevilla and T. Chavez-Lindell and F. Maruri and S. Dorman and W. Cronin and E. Munk and A. Khan and Y. Yuan and B. Chen and F. Yan and Y. Shen and H. Zhao and H. Zhang and P. Bessler and M. Fagley and M. Reichler and J. Tapia and C. Hirsch and C. Luo",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",
year = "2020",
month = jul,
day = "31",
doi = "10.1186/s12879-020-05185-2",
language = "English",
volume = "20",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central",
number = "1",
}
TY - JOUR
T1 - Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada
AU - Reichler, Mary R.
AU - Hirsch, Christina
AU - Yuan, Yan
AU - Khan, Awal
AU - Dorman, Susan E.
AU - Schluger, Neil
AU - Sterling, Timothy R.
AU - Bakhtawar, I.
AU - Ledoux, C.
AU - McAuley, J.
AU - Beison, J.
AU - Fitzgerald, M.
AU - Naus, M.
AU - Nakajima, M.
AU - Schluger, N.
AU - Hirsch-Moverman, Y.
AU - Moran, J.
AU - Blumberg, H.
AU - Tapia, J.
AU - Singha, L.
AU - Hershfeld, E.
AU - Roche, B.
AU - Mangura, B.
AU - Sevilla, A.
AU - Chavez-Lindell, T.
AU - Maruri, F.
AU - Dorman, S.
AU - Cronin, W.
AU - Munk, E.
AU - Khan, A.
AU - Yuan, Y.
AU - Chen, B.
AU - Yan, F.
AU - Shen, Y.
AU - Zhao, H.
AU - Zhang, H.
AU - Bessler, P.
AU - Fagley, M.
AU - Reichler, M.
AU - Tapia, J.
AU - Hirsch, C.
AU - Luo, C.
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/7/31
Y1 - 2020/7/31
N2 - Background: We examined cytokine immune response profiles among contacts to tuberculosis patients to identify immunologic and epidemiologic correlates of tuberculosis. Methods: We prospectively enrolled 1272 contacts of culture-confirmed pulmonary tuberculosis patients at 9 United States and Canadian sites. Epidemiologic characteristics were recorded. Blood was collected and stimulated with Mycobacterium tuberculosis culture filtrate protein, and tumor necrosis factor (TNF-α), interferon gamma (IFN-γ), and interleukin 10 (IL-10) concentrations were determined using immunoassays. Results: Of 1272 contacts, 41 (3.2%) were diagnosed with tuberculosis before or < 30 days after blood collection (co-prevalent tuberculosis) and 19 (1.5%) during subsequent four-year follow-up (incident tuberculosis). Compared with contacts without tuberculosis, those with co-prevalent tuberculosis had higher median baseline TNF-α and IFN-γconcentrations (in pg/mL, TNF-α 129 versus 71, P <.01; IFN-γ231 versus 27, P <.001), and those who subsequently developed incident tuberculosis had higher median baseline TNF-α concentrations (in pg/mL, 257 vs. 71, P <.05). In multivariate analysis, contact age < 15 years, US/Canadian birth, and IFN or TNF concentrations > the median were associated with co-prevalent tuberculosis (P <.01 for each); female sex (P =.03) and smoking (P <.01) were associated with incident tuberculosis. In algorithms combining young age, positive skin test results, and elevated CFPS TNF-α, IFN-γ, and IL-10 responses, the positive predictive values for co-prevalent and incident tuberculosis were 40 and 25%, respectively. Conclusions: Cytokine concentrations and epidemiologic factors at the time of contact investigation may predict co-prevalent and incident tuberculosis.
AB - Background: We examined cytokine immune response profiles among contacts to tuberculosis patients to identify immunologic and epidemiologic correlates of tuberculosis. Methods: We prospectively enrolled 1272 contacts of culture-confirmed pulmonary tuberculosis patients at 9 United States and Canadian sites. Epidemiologic characteristics were recorded. Blood was collected and stimulated with Mycobacterium tuberculosis culture filtrate protein, and tumor necrosis factor (TNF-α), interferon gamma (IFN-γ), and interleukin 10 (IL-10) concentrations were determined using immunoassays. Results: Of 1272 contacts, 41 (3.2%) were diagnosed with tuberculosis before or < 30 days after blood collection (co-prevalent tuberculosis) and 19 (1.5%) during subsequent four-year follow-up (incident tuberculosis). Compared with contacts without tuberculosis, those with co-prevalent tuberculosis had higher median baseline TNF-α and IFN-γconcentrations (in pg/mL, TNF-α 129 versus 71, P <.01; IFN-γ231 versus 27, P <.001), and those who subsequently developed incident tuberculosis had higher median baseline TNF-α concentrations (in pg/mL, 257 vs. 71, P <.05). In multivariate analysis, contact age < 15 years, US/Canadian birth, and IFN or TNF concentrations > the median were associated with co-prevalent tuberculosis (P <.01 for each); female sex (P =.03) and smoking (P <.01) were associated with incident tuberculosis. In algorithms combining young age, positive skin test results, and elevated CFPS TNF-α, IFN-γ, and IL-10 responses, the positive predictive values for co-prevalent and incident tuberculosis were 40 and 25%, respectively. Conclusions: Cytokine concentrations and epidemiologic factors at the time of contact investigation may predict co-prevalent and incident tuberculosis.
UR - http://www.scopus.com/inward/record.url?scp=85089127897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089127897&partnerID=8YFLogxK
U2 - 10.1186/s12879-020-05185-2
DO - 10.1186/s12879-020-05185-2
M3 - Article
C2 - 32736606
AN - SCOPUS:85089127897
SN - 1471-2334
VL - 20
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
IS - 1
M1 - 553
ER -
