Sibling Aggregation for Psychopathology in Offspring of Opiate Addicts: Effects of Parental Comorbidity

Richard Rende; Myrna M. Weissman

doi:10.1207/S15374424jccp280306

Sibling Aggregation for Psychopathology in Offspring of Opiate Addicts: Effects of Parental Comorbidity

Richard Rende, Myrna M. Weissman

Vagelos College of Physicians and Surgeons

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Applied a new analytic approach within the high-risk paradigm, the analysis of sibling aggregation, to identify homogeneous subtypes of familial risk for psychopathology and addiction. All sibling pairs participating in a study of offspring of opiate-addicted parents were identified and their aggregation for psychiatric disorders was determined usingpairwise odds ratios, an analytic technique used in genetic epidemiology. Sibling aggregation was most notable for depressive and anxiety disorders but only in the presence of comorbid depressive disorders in the parents. Parental comorbid alcoholism did not impact sibling aggregation. We emphasize methodological implications of this approach for addressing issues of phenotypic and etiologic heterogeneity in the study of developmental risk for substance abuse.

Original language	English
Pages (from-to)	342-348
Number of pages	7
Journal	Journal of Clinical Child and Adolescent Psychology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1207/S15374424jccp280306
Publication status	Published - 1999

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grant DA07201 awarded to Myrna M. Weissman and an Aaron Diamond Postdoctoral Fellowship in the Biomedical and Social Sciences, a National Alliance on Research on Schizophrenia and Affective Disorders Young Investigator Award, and a Mentored Research Scientist Development Award (MH01559) given to Richard Rende.

Funding

This work was supported by National Institutes of Health Grant DA07201 awarded to Myrna M. Weissman and an Aaron Diamond Postdoctoral Fellowship in the Biomedical and Social Sciences, a National Alliance on Research on Schizophrenia and Affective Disorders Young Investigator Award, and a Mentored Research Scientist Development Award (MH01559) given to Richard Rende.

Funders	Funder number
National Institutes of Health	DA07201
National Institute of Mental Health	K01MH001559

ASJC Scopus Subject Areas

Developmental and Educational Psychology
Clinical Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1207/S15374424jccp280306

Cite this

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abstract = "Applied a new analytic approach within the high-risk paradigm, the analysis of sibling aggregation, to identify homogeneous subtypes of familial risk for psychopathology and addiction. All sibling pairs participating in a study of offspring of opiate-addicted parents were identified and their aggregation for psychiatric disorders was determined usingpairwise odds ratios, an analytic technique used in genetic epidemiology. Sibling aggregation was most notable for depressive and anxiety disorders but only in the presence of comorbid depressive disorders in the parents. Parental comorbid alcoholism did not impact sibling aggregation. We emphasize methodological implications of this approach for addressing issues of phenotypic and etiologic heterogeneity in the study of developmental risk for substance abuse.",

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Sibling Aggregation for Psychopathology in Offspring of Opiate Addicts: Effects of Parental Comorbidity

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

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