Columbia University Irving Medical Center

Proyectos

Proyectos por año 1984 2009 2022 2023 2024 2028

• 17 No iniciado
• 704 Activo
• 2419 Terminado

Proyectos por año

Resultados de la búsqueda

• Terminado

  Role of clearance of toxic metabolites in mitochondrial and tau pathology

  Yan, S. S. S. (PI)

  9/1/23 → 5/31/24

  Proyecto

  • Toxin 100%
  • Glyoxalase 100%
  • Tau 100%
  • Metabolite 100%
  • Nervous System Inflammation 83%

• Association of cumulative exposure to metformin and other T2D medications with cognitive impairment and AD/ADRD biomarkers

  Luchsinger, J. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Biological Marker 100%
  • Maturity Onset Diabetes of the Young 100%
  • Glycon 100%
  • Alzheimer's Disease 100%
  • Cognitive Defect 100%

• Defining the functional role of CD56 on human natural killer cells

  Mace, E. M. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Natural Killer Cell 100%
  • Neural Cell Adhesion Molecule 90%
  • Glycoprotein 20%
  • Viral Disease 10%
  • Target Cell 10%

• Cognitive Assessment and Adjudication Core

  Goldberg, T. T. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Alzheimer's Disease 100%
  • Cognitive Assessment 100%
  • Functional Testing 100%
  • Diabetes 80%
  • Quality Management 66%

• Inhibition of CD33-sialic acid binding in Late-Onset Alzheimer's Disease

  Green, J. J. L. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • CD33 100%
  • Sialic Acid 100%
  • Alzheimer's Disease 100%
  • Peptides 53%
  • Amyloid Protein 26%

• Hormone Therapy for Peri- and Postmenopausal Women with HIV (HoT)

  Yin, M. T. (PI) & Bares, S. S. H. (CoPI)

  9/1/23 → 8/31/24

  Proyecto

  • Human Immunodeficiency Virus 100%
  • Climacterium 100%
  • Hormone Therapy 100%
  • Postmenopause 100%
  • HIV 100%

• Novel Therapeutics for Timothy Syndrome and Related Cardiac Channelopathy

  Yazawa, M. M. (PI)

  9/1/23 → 5/31/24

  Proyecto

  • Cardiac Channelopathy 100%
  • Long QT Syndrome 100%
  • Heart Arrhythmia 100%
  • Syndrome 100%
  • Genetic Disorder 100%

• Nanoluciferase reporter phage for rapid phenotypic characterization of resistance to next-generation antimycobacterial agents

  O'Donnell, M. (PI), Perumal, R. (CoPI) & Jacobs, W. R. (CoPI)

  9/1/23 → 8/31/24

  Proyecto

  • Antimycobacterial Agent 100%
  • Bacteriophage 100%
  • Drug Sensitivity 75%
  • Bedaquiline 50%
  • Rifampicin 50%

• Core A: Administrative Core

  Chung, W. W. K. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Research Project 100%
  • Assessment Center 100%
  • Genetic Risk 100%
  • Administrative Structure 75%
  • Autism 75%

• A daily diary examination of the influence of intersectional stigma on blood pressure

  Caceres, B. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Stigma 100%
  • Blood Pressure 100%
  • Cardiovascular System 26%
  • Health Disparity 16%
  • Social Support 16%

• Applying a multidimensional measure of human mobility to understand drivers of HIV incidence in Rakai, Uganda

  Khalifa, A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • African Country 100%
  • Broad Category 100%
  • Program Objective 100%
  • Treatment Outcome 100%
  • Service Delivery 100%

• Cognitive impairment in the DPPOS cohort and its neuropathologic, neurophysiologic, sociodemographic, and behavioral correlates

  Noble, J. J. M. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Neurodegeneration 100%
  • Diabetes Prevention 100%
  • Cohort Analysis 100%
  • Maturity Onset Diabetes of the Young 100%
  • Cognitive Defect 100%

• Long-term exposure to arsenic, and the co-occurrence of uranium, in public and private drinking water: associations with cardiovascular and chronic kidney diseases in the California Teachers Study

  Medgyesi, D. D. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Long Term Exposure 100%
  • Chronic Kidney Failure 100%
  • Cardiovascular System 100%
  • Drinking Water 100%
  • Cardiovascular Disease 71%

• New York Regional Inborn Errors of Immunity Resource Initiative League (NY-ROYAL)

  Milner, J. J. D. (PI) & Bogunovic, D. D. (CoPI)

  9/1/23 → 8/31/24

  Proyecto

  • Genome Sequencing 100%
  • Primary Immunodeficiency 100%
  • Diagnosis 50%
  • Patient Referral 50%
  • Gene Therapy 50%

• Core B: Statistical and Computational Analysis Core

  Wall, M. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Genetic Risk 100%
  • Caregiver 100%
  • Risk Evaluation 71%
  • Autism 71%
  • Genomics 57%

• Clinical Operations and Procedures Core

  Temprosa, M. M. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Diabetes Prevention 100%
  • Alzheimer's Disease 87%
  • Electrocardiogram 62%
  • Biological Marker 50%
  • Cardiology 25%

• Discovery and Development of a Benzoquinone Molecule as a Novel Anesthetic

  Levy, R. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Quinone 100%
  • Coenzyme 100%
  • Ubiquinone 100%
  • Benzoquinone 100%
  • Mitochondrion 66%

• Uranium exposure in drinking water and cardiovascular disease in the Strong Heart Study

  Lieberman-Cribbin, W. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Urinary System 100%
  • Cardiovascular Disease 100%
  • United States 100%
  • Potable Water 100%
  • American Indian 50%

• Evaluating the effect of water fluoridation on adverse birth outcomes

  Goin, D. E. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Birth Outcomes 100%
  • Water Fluoridation 100%
  • Low Birth Weight 100%
  • Premature Labor 100%
  • Exposure Assessment 100%

• Project 3: Developmental trajectories in infants at genetic risk for autism

  Amso, D. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Developmental trajectories 100%
  • Autism 100%
  • Nerve Cell Differentiation 40%
  • Early Intervention 33%
  • Statistical Modeling 33%

• Administrative and Engagement Core

  Castor, D. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • South Africa 100%
  • Best Practice 100%
  • Screening 100%
  • Decision Making 100%
  • Resource Sharing 100%

• Research Capacity Building Core

  Denny, L. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Capacity Building 100%
  • Implementation Science 100%
  • Cutting Edge 100%
  • Sustainable Building 100%
  • Application Development 100%

• Computational and theoretical understanding of regulatory mechanisms shaping natural vision

  Toosi, T. (PI)

  9/1/23 → 6/30/24

  Proyecto

  • Computer Vision 100%
  • Regularization 100%
  • Natural Image 50%
  • Scale Model 50%
  • Theoretical Framework 25%

• Structure and mechanism of pendrin and the mutations that cause Pendred's Syndrome

  Quick, M. M. (PI) & Zhou, M. (CoPI)

  9/1/23 → 5/31/24

  Proyecto

  • Pendrin 100%
  • Pendred Syndrome 100%
  • Syndrome 21%
  • Niflumic Acid 14%
  • Binding Site 14%

• Methods for inferring and analyzing gene regulatory networks using single-cell multiomics and spatial genomics data

  Hou, W. W. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Gene Control 100%
  • Gene Regulatory Network 100%
  • Genomics 100%
  • Transcriptomics 22%
  • Epigenomics 22%

• Immune and transcriptomic biomarkers of progressive oral premalignant lesions

  Momen Heravi, F. F. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Biological Marker 100%
  • Leukoplakia 100%
  • Transcriptomics 100%
  • Disease 100%
  • Immunity 100%

• Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors

  Baldwin, M. R. (PI)

  9/1/23 → 7/31/24

  Proyecto

  • Acute Respiratory Distress Syndrome 100%
  • Immunity 100%
  • Adult Respiratory Distress Syndrome 100%
  • Biological Marker 18%
  • Mitochondrial Disorder 18%

• Project 1: Identifying and optimizing monogenetic risk prediction for autism in newborns

  Chung, W. W. K. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Genetics 100%
  • Genetic Divergence 100%
  • Genetic Risk 100%
  • Genomics 100%
  • Urban Population 66%

• Examining Individuals' Exposure to Alcohol Environments Using Novel Responsive Buffers

  Mehranbod, C. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Risk Factor 100%
  • Systematic Review 100%
  • Research and Development 100%
  • Alcohol Consumption 100%
  • Individual Level 100%

• Physical activity, physical function, and frailty in relation to cognitive impairment and AD/ADRD biomarkers in DPPOS

  Palta, P. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Biological Marker 100%
  • Physical Activity 100%
  • Frailty 100%
  • Cognitive Defect 100%
  • Cognitive Disorders 100%

• Biostatistics and Data Infrastructure core

  Temprosa, M. M. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Data Infrastructure 100%
  • Prevention Program 100%
  • Biostatistics 100%
  • Alzheimer's Disease 100%
  • Data Management 66%

• Administrative Core

  Luchsinger, J. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Administrative Structure 100%
  • Diabetes Prevention 100%
  • Diseases 80%
  • Alzheimer's Disease 66%
  • Education Program 40%

• ECM remodeling and crosstalk with cell fate in zebrafish ligament regeneration

  Mo, J. J. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Legumain 100%
  • Cell Fate 100%
  • Zebra Fish 100%
  • Macrophage 55%
  • Cysteine Protease 11%

• Administrative Core

  Califano, A. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Pilot Project 100%
  • Steering Committee 100%
  • Administrative Structure 100%
  • Progress Report 50%
  • Metrics 50%

• Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

  Izar, B. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Cancer Cell 100%
  • Tumor Progression 100%
  • Drug Resistance 66%
  • Immunity 66%
  • Human Study 33%

• Drug Mechanism of Action-based targeting of tumor subpopulations

  Califano, A. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Immune Checkpoints 100%
  • Small Molecule 100%
  • Oncogene 100%
  • Drug Mechanism 100%
  • Mouse Model 100%

• Outreach Core

  Murray, D. D. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Outreach 100%
  • Therapy 100%
  • Systems Biology 36%
  • Secondary Schools 36%
  • Scientists 27%

• Advanced Single Cell Technology Innovation Core

  Sims, P. P. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • RNA Sequencing 100%
  • Malignant Neoplasm 100%
  • RNA 100%
  • Analytic Method 50%
  • Neoplasm 50%

• Project 3: A Transdisciplinary Approach to Increasing Phytonutrients in New Mexican Diets: A Kitchen-to-Lab-to-Table Model

  Greenlee, H. A. (PI)

  9/1/23 → 8/31/24

  Proyecto

  • Phytonutrients 100%
  • Chlorophyll 100%
  • Carotenoid 100%
  • Diet Quality 75%
  • Tocopherol 50%

• Uncovering novel mechanisms and potential therapeutic targets for IgA vasculitis through GWAS and systems-level analysis of regulatory networks.

  Liu, L. L. (PI)

  8/24/23 → 5/31/24

  Proyecto

  • IgA Vasculitis 100%
  • Genome Wide Association Study 100%
  • Regulatory Network 100%
  • Genetics 100%
  • Immunoglobulin A 100%

• Health Disparities in Hospice in Nursing Homes

  Stone, P. W. (PI), Dick, A. W. (CoPI) & Dhingra, L. (CoPI)

  8/23/23 → 6/30/24

  Proyecto

  • Nursing Home 100%
  • Health Disparity 100%
  • Hospice Care 40%
  • Terminal Care 20%
  • End of Life Care 20%

• Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma

  Taylor, A. A. M. (PI)

  8/21/23 → 7/31/24

  Proyecto

  • Aneuploidy 100%
  • Chromosome 3 100%
  • Chromosome Arm 50%
  • Chromosome 3q 50%
  • Carcinogenesis 33%

• Architecture, dynamics and regulation of erythrocyte ankyrin-1 complexes

  Clarke, O. O. B. (PI)

  8/20/23 → 7/31/24

  Proyecto

  • Dynamics 100%
  • Ankyrin 100%
  • Band 3 30%
  • Membrane Protein 30%
  • Transmembrane Protein 30%

• Development and application of a quantitive model for HIV-1 transcriptional activation driven by TAR RNA conformational dynamics

  Al-hashimi, H. H. M. (PI), Herschlag, D. D. (CoPI) & Goff, S. S. P. (CoPI)

  8/17/23 → 7/31/24

  Proyecto

  • Dynamics 100%
  • Human Immunodeficiency Virus 1 100%
  • Transcription Initiation 100%
  • RNA 100%
  • Transactivation 100%

• NY Community-Hospital-Academic Maternal Health Equity Partnerships (NY-CHAMP)

  Reddy, U. U. (PI), Rodriguez, E. E. (CoPI), Li, G. G. (CoPI), Taylor, J. J. Y. (CoPI), Hall, K. K. S. (CoPI), Osborne, L. L. M. (CoPI), Dorval-moller, M. M. (CoPI), Safford, M. M. M. (CoPI), Brown, S. S. (CoPI) & St. Clair, V. V. (CoPI)

  8/17/23 → 7/31/24

  Proyecto

  • Maternal Welfare 100%
  • Health Disparity 12%
  • Patient Care 12%
  • Health Care Cost 12%
  • Cognitive Behavioral Therapy 12%

• Non-APOL1 genetic factors and kidney transplant outcomes

  Kiryluk, K. K. (PI)

  8/15/23 → 5/31/24

  Proyecto

  • Heredity 100%
  • Kidney Graft 100%
  • Kidney Transplantation 100%
  • Genetics 100%
  • Genetic Determinism 100%

• Investigating the role of long-term latent herpes simplex virus infection on APOE4-associated Alzheimer's disease pathogenesis

  Nuriel, T. T. (PI) & Cliffe, A. A. R. (CoPI)

  8/15/23 → 4/30/24

  Proyecto

  • Virus Infection 100%
  • Human Alphaherpesvirus 1 100%
  • Herpes Simplex Virus 100%
  • Alzheimer's Disease 100%
  • Infection 83%

• Impact of Environmental Exposures on Lung Immunity over Age

  Ural, B. B. (PI)

  8/15/23 → 4/30/24

  Proyecto

  • Environmental Exposure 100%
  • Macrophage 100%
  • Lung 100%
  • Diseases 100%
  • Lymph Node 71%

• Molecular Mechanisms of MDS pathogenesis with aging

  Kousteni, S. S. (PI)

  8/15/23 → 4/30/24

  Proyecto

  • Nucleoporin 100%
  • Stem Cell 37%
  • Hematopoiesis 12%
  • NUP98 12%
  • Molecular Genetics 12%

• Identification of smooth muscle cell genes causal in atherosclerotic plaque stability and cardiovascular disease risk

  Reilly, M. M. P. (PI) & Saleheen, D. D. (CoPI)

  8/10/23 → 6/30/24

  Proyecto

  • Mouse Model 100%
  • Single Nucleotide Polymorphism 66%
  • Pleiotropy 66%
  • RNA 66%
  • Genetics 33%