Detalles del proyecto
Description
This interdisciplinary investigation is aimed at determining the
ANISOTROPIC and INHOMOGENEOUS biomechanical properties
of normal bovine and human meniscal tissue. Variations in these
properties with orientation relative to the predominant collagen
fiber directions, location within the meniscus, and between the
medial and lateral menisci will be examined. The motivation for
this study is the well documented SIGNIFICANT ROLE THAT THE
MENISCI PLAY IN THE FUNCTION OF THE KNEE AND THE
LIMITED INFORMATION AVAILABLE REGARDING THE
MATERIAL PROPERTIES AND MECHANICAL FUNCTION OF
NORMAL MENISCI. Finite element models will be developed
using and anisotropic formulation of the biphasic theory to
correspond with tissue structure and composition. Specific
geometric configurations which accurately represent the
experiments will be developed for the determination of tissue
properties. Medial and lateral menisci from healthy, skeletally
mature bovine and human knee joints will be used. The
experimental tests to be employed are: 1) constant strain rate
tensile tests, on specimens harvested parallel and perpendicular to
the collagen fiber directions, to determine the tensile stress-
strain behavior; 2) transient shear relaxation and steady-state
dynamic shear tests, on disks oriented in three mutually
perpendicular directions, to determine the anisotropic "flow-
independent" shear properties; and 3) an "unconfined" compression
test, on disk oriented in the same three mutually perpendicular
directions, to determine the anisotropic equilibrium compressive
properties and solid matrix permeability. A series of finite
element models, with increasing geometric and material
sophistication, will be constructed--starting with single phase
transversely isotropic linearly elastic models and progressing to
transversely isotropic linear biphasic theories use for soft
hydrated tissue. These models will range from axisymmetric to
full three-dimensional representations and will include
nonlinearities such as the strain dependent permeability effect
and the compressive shear stiffening effect.
Estado | Finalizado |
---|---|
Fecha de inicio/Fecha fin | 5/1/88 → 4/30/92 |
Financiación
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
Keywords
- Biofísica
Huella digital
Explore los temas de investigación que se abordan en este proyecto. Estas etiquetas se generan con base en las adjudicaciones/concesiones subyacentes. Juntos, forma una huella digital única.