Creating and Deploying a Toolkit for Human Microglia in Neurodegeneration

Recent convergent work has put a spotlight on microglial cells in the brain as a key part of the brain's immune response in a broad range of neurodegenerative diseases. The field has lacked robust and reliable tools for dissecting the role of these cells, especially in human samples. To address this gap, this team will generate key reference data and a microglia experimental toolkit to identify and target different human microglial subtypes, with plans to make these tools available to the broader research community.