Diet and Cognition within a Reserve framework

Relevance Mediterranean-type diet has been increasingly identified as playing an important role in preventing Alzheimer’s disease and cognitive decline in the elderly, but the mechanisms remain unclear. Several reserve concepts, including brain reserve, brain maintenance, and cognitive reserve, collectively explain individual differences in cognition, function or clinical status relative to aging and brain disease. In this proposal, using data from two well-established imaging cohorts we will examine the respect roles of brain reserve, brain maintenance, and cognitive reserve in cognitive benefits of Mediterranean-type diet.