Does Pathology in Locus Coeruleus Trigger AD?

The locus coeruleus (LC) of the brain is important for sleep and memory, but it's unclear if accumulation of tau in its neurons is an early sign of Alzheimer's disease. By studying the electrical activity of LC neurons in mice, we will determine if tau prevents LC to function normally and causes sleep and memory problems. In addition, we will manipulate the activity of the LC neurons in order to restore its function and reverse sleep and memory impairment.