Identification of unique nitric oxide-expressing hematopoietic stem cells and their special vascular niche

Project Narrative The goal of the proposed project is to identify most primitive blood stem cells among others, and elucidate how these primitive blood stem cells are controlled and protected by the surrounding cells within the bone marrow, the place for blood generation. Successful studies will lead to new treatment strategies to improve outcomes of patients with hematopoiesis failure by dampening stress against blood stem cells.