Machine Learning & Impaired Spatial Decoding in AD Mice

Complex information processing in the brain is possible due to the combined strength and diverse talents of large numbers of neurons working together. In mouse models of Alzheimer's disease (AD) pathology, amyloid beta (Aβ) leads to overactive neuron signaling and poor spatial information processing, which may be aggravated by tau build-up. Using sophisticated recording techniques, we will measure the content and quality of spatial information transmitted by large numbers of neurons in brains containing Aβ and tau pathology. Dysfunctional neuronal populations will be selectively targeted to correct their overactive firing patterns, with the overall goal of improving the quality of spatial information carried by large numbers of neurons.