TARGETING EPIGENETIC PLASTICITY AND DRUG RESISTANCE IN PEDIATRIC CANCER

  • Ferrando, Adolfo A (CoPI)
  • Stegmaier, Kimberly (PI)

Proyecto

Detalles del proyecto

Description

Treatment options for patients whose cancer returns are often limited because their cancer cells have become resistant to chemotherapy. It is thought that distinct subgroups of cells in the primary tumor are differentially sensitive to chemotherapy and that cells can become drug-resistant through epigenetic changes (modifications in the DNA that activate or inactivate genes). Drs. Stegmaier and Ferrando worked to define the factors involved in chemotherapy resistance in acute lymphoblastic leukemia and Ewing sarcoma.

EstadoActivo
Fecha de inicio/Fecha fin7/1/15 → …

Financiación

  • American Association for Cancer Research: $250,000.00

Keywords

  • Investigación sobre el cáncer
  • Genética
  • Biología molecular
  • Oncología
  • Pediatría, perinaltología y salud infantil

Huella digital

Explore los temas de investigación que se abordan en este proyecto. Estas etiquetas se generan con base en las adjudicaciones/concesiones subyacentes. Juntos, forma una huella digital única.