Stasiak, M., Imhauser, C., Packer, J., Bedi, A., Brophy, R., Kovacevic, D., Jackson, K., Deng, X. H., Rodeo, S., & Torzilli, P. (2010). A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction. Journal of Medical Devices, Transactions of the ASME, 4(1). https://doi.org/10.1115/1.4001158
A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction. / Stasiak, Mark; Imhauser, Carl; Packer, Jonathan et al.
En:
Journal of Medical Devices, Transactions of the ASME, Vol. 4, N.º 1, 03.2010.
Producción científica › revisión exhaustiva
Stasiak, M, Imhauser, C, Packer, J, Bedi, A, Brophy, R, Kovacevic, D, Jackson, K, Deng, XH, Rodeo, S & Torzilli, P 2010, 'A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction', Journal of Medical Devices, Transactions of the ASME, vol. 4, n.º 1. https://doi.org/10.1115/1.4001158
Stasiak M, Imhauser C, Packer J, Bedi A, Brophy R, Kovacevic D et al. A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction. Journal of Medical Devices, Transactions of the ASME. 2010 mar.;4(1). doi: 10.1115/1.4001158
Stasiak, Mark ; Imhauser, Carl ; Packer, Jonathan et al. / A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction. En: Journal of Medical Devices, Transactions of the ASME. 2010 ; Vol. 4, N.º 1.
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title = "A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction",
abstract = "We designed and validated a novel knee joint fixation/distraction system to study tendon-to-bone healing in an in vivo rat model of anterior cruciate ligament (ACL) reconstruction. The system uses an external fixator to apply a cyclic distraction of the knee joint while monitoring the resultant force developed across the joint, thus providing a temporal indication of structural changes during the healing process of the bone-tendon-bone reconstruction. The validation was performed using an optical kinematic tracking system to determine the local displacement of the knee. The average system compliance was determined to be 42.4±8.8 μm/N with a coefficient of variation of 20.7%. The compliance was used to obtain a best fit correction factor which brought the total root mean square error of knee joint distraction to within 179 μm (16.1%) of the applied distraction. We performed a pilot study using 15 rats that had ACL reconstructions using a flexor digitorum longus tendon autograft and found that the animals tolerated the indwelling fixator and daily anesthesia over a 10 day loading protocol. Our knee joint fixation/distraction system provides a valuable tool to study how mechanical stimuli affect in vivo bone-tendon-bone healing.",
author = "Mark Stasiak and Carl Imhauser and Jonathan Packer and Asheesh Bedi and Robert Brophy and David Kovacevic and Kent Jackson and Deng, {Xiang Hua} and Scott Rodeo and Peter Torzilli",
year = "2010",
month = mar,
doi = "10.1115/1.4001158",
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journal = "Journal of Medical Devices, Transactions of the ASME",
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T1 - A novel in vivo joint loading system to investigate the effect of daily mechanical load on a healing anterior cruciate ligament reconstruction
AU - Stasiak, Mark
AU - Imhauser, Carl
AU - Packer, Jonathan
AU - Bedi, Asheesh
AU - Brophy, Robert
AU - Kovacevic, David
AU - Jackson, Kent
AU - Deng, Xiang Hua
AU - Rodeo, Scott
AU - Torzilli, Peter
PY - 2010/3
Y1 - 2010/3
N2 - We designed and validated a novel knee joint fixation/distraction system to study tendon-to-bone healing in an in vivo rat model of anterior cruciate ligament (ACL) reconstruction. The system uses an external fixator to apply a cyclic distraction of the knee joint while monitoring the resultant force developed across the joint, thus providing a temporal indication of structural changes during the healing process of the bone-tendon-bone reconstruction. The validation was performed using an optical kinematic tracking system to determine the local displacement of the knee. The average system compliance was determined to be 42.4±8.8 μm/N with a coefficient of variation of 20.7%. The compliance was used to obtain a best fit correction factor which brought the total root mean square error of knee joint distraction to within 179 μm (16.1%) of the applied distraction. We performed a pilot study using 15 rats that had ACL reconstructions using a flexor digitorum longus tendon autograft and found that the animals tolerated the indwelling fixator and daily anesthesia over a 10 day loading protocol. Our knee joint fixation/distraction system provides a valuable tool to study how mechanical stimuli affect in vivo bone-tendon-bone healing.
AB - We designed and validated a novel knee joint fixation/distraction system to study tendon-to-bone healing in an in vivo rat model of anterior cruciate ligament (ACL) reconstruction. The system uses an external fixator to apply a cyclic distraction of the knee joint while monitoring the resultant force developed across the joint, thus providing a temporal indication of structural changes during the healing process of the bone-tendon-bone reconstruction. The validation was performed using an optical kinematic tracking system to determine the local displacement of the knee. The average system compliance was determined to be 42.4±8.8 μm/N with a coefficient of variation of 20.7%. The compliance was used to obtain a best fit correction factor which brought the total root mean square error of knee joint distraction to within 179 μm (16.1%) of the applied distraction. We performed a pilot study using 15 rats that had ACL reconstructions using a flexor digitorum longus tendon autograft and found that the animals tolerated the indwelling fixator and daily anesthesia over a 10 day loading protocol. Our knee joint fixation/distraction system provides a valuable tool to study how mechanical stimuli affect in vivo bone-tendon-bone healing.
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