TY - JOUR
T1 - Clomipramine treatment of panic disorder
T2 - Pros and cons
AU - Papp, Laszlo A.
AU - Schneier, Franklin R.
AU - Fyer, Abby J.
AU - Liebowitz, Michael R.
AU - Gorman, Jack M.
AU - Coplan, Jeremy D.
AU - Campeas, Raphael
AU - Fallon, Brian A.
AU - Klein, Donald F.
PY - 1997
Y1 - 1997
N2 - Background: Controlled trials suggest that clomipramine may be a highly effective antipanic drug. Lowering the starting dose may alleviate troublesome initial side effects and increase acceptability and compliance. Method: Fifty-eight patients with DSM-III-R panic disorder with or without agoraphobia underwent 13 weeks of clomipramine treatment. Starting at 10 mg/day, the dose was gradually increased to a mean dose of 97 mg/day. Results: While completers showed highly significant improvement, the benefits were severely limited by a high dropout rate due to adverse reactions occurring mostly during the first 2 weeks of treatment. Conclusion: Given the alternatives, clomipramine should not be used as a first-line antipanic medication.
AB - Background: Controlled trials suggest that clomipramine may be a highly effective antipanic drug. Lowering the starting dose may alleviate troublesome initial side effects and increase acceptability and compliance. Method: Fifty-eight patients with DSM-III-R panic disorder with or without agoraphobia underwent 13 weeks of clomipramine treatment. Starting at 10 mg/day, the dose was gradually increased to a mean dose of 97 mg/day. Results: While completers showed highly significant improvement, the benefits were severely limited by a high dropout rate due to adverse reactions occurring mostly during the first 2 weeks of treatment. Conclusion: Given the alternatives, clomipramine should not be used as a first-line antipanic medication.
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U2 - 10.4088/JCP.v58n1002
DO - 10.4088/JCP.v58n1002
M3 - Article
C2 - 9375591
AN - SCOPUS:0030666169
SN - 0160-6689
VL - 58
SP - 423
EP - 425
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 10
ER -
