Frequent K-ras mutations in small bowel adenocarcinomas

Thomas Sutter, Nadir Arber, Steven F. Moss, Richard I. Findling, Alfred I. Neugut, I. Bernard Weinstein, Peter R. Holt

Producción científicarevisión exhaustiva

41 Citas (Scopus)

Resumen

The reasons for the relatively rare occurrence of small bowel adenocarcinomas when compared to the high frequency of colonic adenocarcinomas are unknown. Activating mutations in the K-ras oncogene occur in about 40% of colonic adenocarcinomas, possibly reflecting the consequences of carcinogenic exposure. To study whether the low incidence of small bowel adenocarcinomas might be due to the absence of activation of cellular oncogenes in small bowel adenocarcinomas, we examined the frequency of K-ras mutations in small bowel adenocarcinomas. K-ras mutations were determined using a polymerase chain reaction (PCR)-based method to detect codon 12 mutations by restriction fragment length polymorphism. PCR amplification was successful in six of nine small bowel adenocarcinoma samples, and revealed point mutations of K-ras at codon 12 in five of these six cases. We conclude that the small bowel might be exposed to carcinogens similar to those responsible for colorectal cancer, but may have developed protective mechanisms against cancer formation.

Idioma originalEnglish
Páginas (desde-hasta)115-118
Número de páginas4
PublicaciónDigestive Diseases and Sciences
Volumen41
N.º1
DOI
EstadoPublished - 1996

ASJC Scopus Subject Areas

  • Physiology
  • Gastroenterology

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