Myocardial G proteins in murine Chagas' disease

Huan Huang, Herbert B. Tanowitz, John P. Bilezikian, Murray Wittner, Louis M. Weiss, Stephen A. Morris

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5 Citas (Scopus)

Resumen

G protein α subunits and their corresponding mRNA levels were determined in hearts obtained from mice infected with Trypanosoma cruzi, the etiologic agent of Chagas' disease. Protein and mRNA levels of the inhibitory G proteins G(αi2) and G(αi3) were increased at 21 and 30 days postinfection (PI). After 60 days, the abundance of protein and corresponding mRNA for G(αi2) and G(αi3) were no longer significantly different from uninfected mice. Twenty-one days after infection. G(αs) protein levels decreased markedly, but mRNA for the stimulatory protein did not change. Similar to the G(i) proteins, by 60 days differences in G(αs) protein between infected and uninfected mice were no longer evident. There was an increase in the magnitude of G(β) subunit protein 21 and 30 days PI as compared with uninfected mice. However, 60 days PI the G(β) subunit protein decreased to control levels. The close relationship between the infection-associated increase in G(αi) protein and mRNA suggests that control of protein expression is likely to be exerted at the transcription level. In contrast, control of infection-associated decrease in G(s) appears to be at the translational level.

Idioma originalEnglish
Páginas (desde-hasta)663-670
Número de páginas8
PublicaciónJournal of Parasitology
Volumen83
N.º4
DOI
EstadoPublished - ago. 1997

Financiación

FinanciadoresNúmero del financiador
National Institute of Allergy and Infectious DiseasesR01AI012770

    ASJC Scopus Subject Areas

    • Parasitology
    • Ecology, Evolution, Behavior and Systematics

    Huella

    Profundice en los temas de investigación de 'Myocardial G proteins in murine Chagas' disease'. En conjunto forman una huella única.

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    Huang, H., Tanowitz, H. B., Bilezikian, J. P., Wittner, M., Weiss, L. M., & Morris, S. A. (1997). Myocardial G proteins in murine Chagas' disease. Journal of Parasitology, 83(4), 663-670. https://doi.org/10.2307/3284244