Offspring at High and Low Risk for Depression and Anxiety: Mechanisms of Psychiatric Disorder

Virginia Warner, Laura Mufson, Myrna M. Weissman

Producción científicarevisión exhaustiva

160 Citas (Scopus)

Resumen

To examine the effect of parental psychiatric diagnosis on the risk of psychiatric disorder In their offspring and to determine mediators and independent predictors of psychiatric disorder in offspring. The sample consisted of 145 offspring (between the ages of 6 and 24 years, who were directly interviewed) of probands with early-onset (before age 30 years) major depressive disorder (MDD) without panic, panic disorder with and without major depression, and a normal, never psychiatrically ill control group who were part of a large study conducted to determine the relationship between panic disorder and major depression. The risk for offspring MDD was increased by proband recurrent early-onset MOD and coparent alcohol abuse. Chaotic family environment was the only independent predictor of dysthymia. The risk for offspring “any anxiety” disorder was increased by proband recurrent early-onset MDD and coparent impaired functioning. The association between MDD In proband and “panic spectrum” disorder in offspring was accounted for by chaotic family environment. Conclusion: Recurrent parental MDD has consistently been shown to be a strong risk factor for offspring MDD Family environment plays an important role in low-level anxiety symptoms and dysthymia. Clinicians treating adults should be alert to risk factors for their offspring and to appropriate targets for early intervention. J. Am. Acad. Child Adolesc. Psychiatry, 1995, 34, 6:786–797.

Idioma originalEnglish
Páginas (desde-hasta)786-797
Número de páginas12
PublicaciónJournal of the American Academy of Child and Adolescent Psychiatry
Volumen34
N.º6
DOI
EstadoPublished - 1995

Financiación

FinanciadoresNúmero del financiador
National Institute of Mental HealthR01MH028274

    ASJC Scopus Subject Areas

    • Developmental and Educational Psychology
    • Psychiatry and Mental health

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