TY - JOUR
T1 - Oxidative stress in pericardial fluid and plasma and its association with ventricular function
AU - Vukasovic, Jose Luis
AU - Moraga, Francisco
AU - Díaz-Araya, Guillermo
AU - Turner, Eduardo
AU - Chiong, Mario
AU - Uriarte, Polentzi
AU - Florenzano, Fernando
AU - Lavandero, Sergio
N1 - Funding Information:
This work was supported in part by grants FONDECYT 1010992, FONDAP 15010006 and Apertus-Andromaco.
PY - 2005/5/25
Y1 - 2005/5/25
N2 - There are no studies evaluating oxidative stress markers both in pericardial fluid and plasma and whether they correlate with cardiac function indexes. The purpose of the study was to investigate whether oxidative stress markers in pericardial fluid and plasma are associated with left ventricular function. Methods and results: Twenty-eight consecutive patients (class I or II NYHA) scheduled for myocardial revascularization, valve replacement, valve repair or closure of atrial septal defect. Plasma and pericardial fluid were collected and malondialdehyde, catalase, superoxide dismutase and glutathione peroxidase were determined. Left ventricular ejection fraction, left ventricular end diastolic diameter and left ventricular end systolic diameter were determined as echocardiographic indexes of ventricular function. We found that oxidative stress determined by a simple malondialdehyde (MDA) assay, correlated in plasma and pericardial fluid, and this parameter was associated with left ventricular end systolic diameter. Conclusion: Plasma and pericardial fluid malondialdehyde levels can be used as an early marker of ventricular dysfunction.
AB - There are no studies evaluating oxidative stress markers both in pericardial fluid and plasma and whether they correlate with cardiac function indexes. The purpose of the study was to investigate whether oxidative stress markers in pericardial fluid and plasma are associated with left ventricular function. Methods and results: Twenty-eight consecutive patients (class I or II NYHA) scheduled for myocardial revascularization, valve replacement, valve repair or closure of atrial septal defect. Plasma and pericardial fluid were collected and malondialdehyde, catalase, superoxide dismutase and glutathione peroxidase were determined. Left ventricular ejection fraction, left ventricular end diastolic diameter and left ventricular end systolic diameter were determined as echocardiographic indexes of ventricular function. We found that oxidative stress determined by a simple malondialdehyde (MDA) assay, correlated in plasma and pericardial fluid, and this parameter was associated with left ventricular end systolic diameter. Conclusion: Plasma and pericardial fluid malondialdehyde levels can be used as an early marker of ventricular dysfunction.
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U2 - 10.1016/j.ijcard.2004.03.013
DO - 10.1016/j.ijcard.2004.03.013
M3 - Article
C2 - 15882663
AN - SCOPUS:18344372748
SN - 0167-5273
VL - 101
SP - 197
EP - 201
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -