TY - JOUR
T1 - Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy
AU - Ebensperger, Roberto
AU - Acevedo, Erika
AU - Meléndez, Jaime
AU - Corbalán, Ramón
AU - Acevedo, Mónica
AU - Sapag-Hagar, Mario
AU - Jalil, Jorge E.
AU - Lavandero, Sergio
N1 - Funding Information:
This work was supported by Grants FONDECYT 1930592, 1950452, and 2960047. R. E. holds a fellowship from CONICYT. We thank Dr. C. I. Pogson for his help in the preparation of this paper.
PY - 1998/2/4
Y1 - 1998/2/4
N2 - There is evidence that insulin-like growth factor-1 (IGF-1) plays a role in the development of left ventricular hypertrophy, but it is uncertain whether cardiac IGP-1 changes before or after hypertension is established, and whether circulating IGF-1 are involved in cardiac hypertrophy. We have investigated changes in circulating and left ventricular IGF-1 and in the expression of the IGF-1 gene in the left ventricles of rats during the development of hypertensive left ventricular hypertrophy (Goldblatt model; 2 kidney-1 clamped). Our results show that the left ventricular contents of IGF-1 and its mRNA were increased at one and four weeks of hypertension and hypertrophy, and that both returned to control values after nine weeks. These changes were unrelated to the seric concentration of IGF-1 in the blood. These results show that local rather than circulating IGF-1 levels contributed to the development of renovascular hypertensive left ventricular hypertrophy.
AB - There is evidence that insulin-like growth factor-1 (IGF-1) plays a role in the development of left ventricular hypertrophy, but it is uncertain whether cardiac IGP-1 changes before or after hypertension is established, and whether circulating IGF-1 are involved in cardiac hypertrophy. We have investigated changes in circulating and left ventricular IGF-1 and in the expression of the IGF-1 gene in the left ventricles of rats during the development of hypertensive left ventricular hypertrophy (Goldblatt model; 2 kidney-1 clamped). Our results show that the left ventricular contents of IGF-1 and its mRNA were increased at one and four weeks of hypertension and hypertrophy, and that both returned to control values after nine weeks. These changes were unrelated to the seric concentration of IGF-1 in the blood. These results show that local rather than circulating IGF-1 levels contributed to the development of renovascular hypertensive left ventricular hypertrophy.
UR - http://www.scopus.com/inward/record.url?scp=0032481289&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032481289&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1997.8031
DO - 10.1006/bbrc.1997.8031
M3 - Article
C2 - 9473472
AN - SCOPUS:0032481289
SN - 0006-291X
VL - 243
SP - 20
EP - 24
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -