Resumen
The surface glycoproteins T4 and T8 define functionally distinct populations of T lymphocytes. We have obtained cDNA and genomic clones encoding the T4 molecule and used these as probes to determine the chromosomal location of this gene. Genomic blotting experiments, along with in situ hybridization analyses, indicate that the T4 gene resides on the short arm of human chromosome 12, at region p12-pter. Thus, the T4 gene is not linked to any known member of the immunoglobulin gene family, including its counterpart gene, T8, which resides on human chromosome 2 immediately distal to the immunoglobulin κ locus.
Idioma original | English |
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Páginas (desde-hasta) | 4399-4402 |
Número de páginas | 4 |
Publicación | Proceedings of the National Academy of Sciences of the United States of America |
Volumen | 83 |
N.º | 12 |
DOI | |
Estado | Published - 1986 |
Financiación
Financiadores | Número del financiador |
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National Cancer Institute | R35CA039860 |
ASJC Scopus Subject Areas
- General
Huella
Profundice en los temas de investigación de 'The gene encoding the T-cell surface protein T4 is located on human chromosome 12'. En conjunto forman una huella única.Citar esto
Isobe, M., Huebner, K., Maddon, P. J., Littman, D. R., Axel, R., & Croce, C. M. (1986). The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proceedings of the National Academy of Sciences of the United States of America, 83(12), 4399-4402. https://doi.org/10.1073/pnas.83.12.4399