Acquisition of 600 MHz NMR QCI-P CryoProbe and CryoPlatform

PROJECT SUMMARY Funding is requested to obtain a Bruker Biospin QCI-P CryoProbe and CryoPlatform to be installed on an existing Bruker Biospin 600 MHz NMR magnet system. The requested instrumentation provides enhanced sensitivity and capabilities for modern NMR experiments, particularly experiments utilizing the 31P nucleus in studies of lipids, phosphoproteins, and nucleic acids. The requested instrumentation will be used by an outstanding set of scientists at Columbia University, at the New York Structural Biology Center, and other nearby research centers. Research conducted on the 600 MHz NMR spectrometer ranges from fundamental studies of structure/function relationships in biomolecules, to molecular conformational dynamics, to elucidation of mechanisms of health and disease. The requested instrumentation will dramatically enhance the hardware capabilities of the existing 600 MHz NMR spectrometer to conduct cutting-edge research.