Autophagy in Neurodegeneration and Neuroinflammation in Glaucoma

Final Report Summary: Glaucoma is a leading cause of blindness affecting millions of Americans. However, current treatment strategies are not sufficient to prevent disease progression. We expect that by improving the molecular understanding of autophagy that impacts both retinal ganglion cell (RGC) survival/axon integrity and glia-driven inflammation, this project will provide translational implications for development of neuroprotective and immunomodulatory treatments for glaucoma.