Détails sur le projet
Description
This investigation will determine the timing and the clinical and
biological significance of brain atrophy and white matter lesions seen in
magnetic resonance imaging (MRI) of patients with human immunodeficiency
virus (HIV). This study is part of an ongoing investigation at the HIV
Center for Behavioral and Clinical Studies at the New York State
Psychiatric Institute which examines the natural history and evolution of
neurological and neuropsychological manifestations of HIV infection in
gay men and parenteral drug abusers of both sexes. The primary objective
of this new investigation is to determine the relationship of
abnormalities on MRI to the prevalence, progression and incidence of
neuropsychological, neurological, and virological parameters of disease
in cerebrospinal fluid (CSF).
We hypothesize that MRI will reveal the earliest signs of central nervous
system infection by HIV. Atrophy and white matter lesions will precede
or occur simultaneously with neurological and neuropsychological changes
and will correlate with virological evidence of infection in CSF. A
representative sample of the cohort being investigated for natural
history of HIV will have MRI on an annual basis and a subsample will have
CSF examinations to determine the psychobiological correlated of the
radiological manifestations. Over four years we intend to determine the
prevalence and incidence of MRI abnormalities in gay men and parenteral
drug abusers who are HIV positive, determine the psychobiological
correlates of these lesions, determine the virological parameters in CSF
and determine their relationship to the HIV Center at the New York State
Psychiatric Institutes, we will also examine the relationship to other
aspects being investigated there, such as psychopathology, sexual
behavior and immune status.
Statut | Terminé |
---|---|
Date de début/de fin réelle | 7/1/89 → 6/30/93 |
Financement
- National Institute of Mental Health
Keywords
- Radiología, medicina nuclear y obtención de imágenes
- Psiquiatría y salud mental
Empreinte numérique
Explorer les sujets de recherche abordés dans ce projet. Ces étiquettes sont créées en fonction des prix/bourses sous-jacents. Ensemble, ils forment une empreinte numérique unique.