Chemical Targeting of Sensors and Pharmacological Probes in the Brain

Project Narrative With the developing understanding of the distinct roles of individual cell types and underlying circuits in the mammalian brain, there is an increasing demand for monitoring and modulation of specific neuronal populations. In this project, we will develop a versatile and modular platform based on small polar polymers for targeting lipophilic sensors, actuators and drugs in brain tissue without the need for genetic manipulation.