Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression

Project Narrative Carriers of the APOE4 gene are at a significantly increased risk of developing Alzheimer’s disease. In order to understand the cause of this increased Alzheimer’s risk, we will conduct a comprehensive investigation of how the APOE genotype affects normal biological pathways in the brain, defining how these effects progress with time and within brain regions and cell-types. Using a new APOE mouse line and cutting-edge technology, these experiments will dramatically improve our understanding of why APOE4 carriers are more susceptible to AD and how this susceptibility can be prevented.