Holographic reprogramming of memories during sleep in a mouse model of Alzheimers disease

Cortical perceptual memory is believed to consolidate during sleep, where organized firing of neuronal ensembles is reactivated similarly to representations formed during learning. Dysregulation of memory reactivation may contribute to the neurocognitive impairments in Alzheimer’s disease (AD). Using state-of-the- art optical techniques, this proposal aims to evaluate the role of memory reactivation during sleep to memory consolidation, as well as identify impairments to and enhance reactivation during sleep in a mouse model of AD.